4-(5-Phenylmethylspirodioxolan>-2-yl)-2-butennitril

Base Information

• Chemical Name: 4-(5-Phenylmethylspirodioxolan>-2-yl)-2-butennitril
• CAS No.: 81978-67-8
• Molecular Formula: C₁₈H₂₁NO₂
• Molecular Weight: 283.37

Synonyms:4-(5-Phenylmethylspirodioxolan>-2-yl)-2-butennitril

Chemical Property of 4-(5-Phenylmethylspirodioxolan>-2-yl)-2-butennitril

Chemical Property:

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Technology Process of 4-(5-Phenylmethylspirodioxolan>-2-yl)-2-butennitril

There total 3 articles about 4-(5-Phenylmethylspirodioxolan>-2-yl)-2-butennitril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-<2-Oxo-3-(phenylmethyl)cyclopentyl>-2-butennitril (81978-63-4) + ethylene glycol (107-21-1) → 4-(5-Phenylmethylspirodioxolan>-2-yl)-2-butennitril (81978-67-8)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 12h; Heating;

Reference yield:

2-benzylcyclopentanone (2867-63-2) → 4-(5-Phenylmethylspirodioxolan>-2-yl)-2-butennitril (81978-67-8)

Guidance literature:

Multi-step reaction with 3 steps

1: benzene / Heating

2: 2) 2 N HCl / 1) CH₃CN, 13 h, reflux, 2) 1 h, reflux

3: 86 percent / p-toluenesulfonic acid / benzene / 12 h / Heating

With hydrogenchloride; toluene-4-sulfonic acid; In benzene;

Reference yield:

1-(5-Benzyl-cyclopent-1-enyl)-piperidine → 4-(5-Phenylmethylspirodioxolan>-2-yl)-2-butennitril (81978-67-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 2) 2 N HCl / 1) CH₃CN, 13 h, reflux, 2) 1 h, reflux

2: 86 percent / p-toluenesulfonic acid / benzene / 12 h / Heating

With hydrogenchloride; toluene-4-sulfonic acid; In benzene;

upstream raw materials:

4-<2-Oxo-3-(phenylmethyl)cyclopentyl>-2-butennitril

ethylene glycol

2-benzylcyclopentanone

Downstream raw materials:

2,3,4,5,5a,6,7,8-Octahydro-8-(phenylmethyl)cyclopentazepin

1,2,3,6,7,8-Hexahydro-3-hydroxy-3-(phenylmethyl)-4H-chinolizin-4-on

1,2,3,6,7,8,9,9a-Octahydro-3,9a-dihydroxy-3-(phenylmethyl)-4H-chinolizin-4-on

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