(R,S)-(4-fluorophenyl)(2-methyl-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-pyrazolo[3,4-d]pyrimidin-6-yl)methanol acetate

Base Information

Chemical Name:(R,S)-(4-fluorophenyl)(2-methyl-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-pyrazolo[3,4-d]pyrimidin-6-yl)methanol acetate
CAS No.:1361960-61-3
Molecular Formula:C₂H₄O₂*C₁₇H₁₆FN₇O
Molecular Weight:413.411
Hs Code.:

Synonyms:(R,S)-(4-fluorophenyl)(2-methyl-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-pyrazolo[3,4-d]pyrimidin-6-yl)methanol acetate

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Chemical Property of (R,S)-(4-fluorophenyl)(2-methyl-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-pyrazolo[3,4-d]pyrimidin-6-yl)methanol acetate

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Technology Process of (R,S)-(4-fluorophenyl)(2-methyl-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-pyrazolo[3,4-d]pyrimidin-6-yl)methanol acetate

There total 5 articles about (R,S)-(4-fluorophenyl)(2-methyl-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-pyrazolo[3,4-d]pyrimidin-6-yl)methanol acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 31230-17-8
3-methyl-5-aminopyrazole

: 1361961-18-3
(4-chloro-2-methyl-2H-pyrazolo[3,4-d]pyrimidin-6-yl)(4-fluorophenyl)methanone

: 64-19-7,77671-22-8
acetic acid

: 1361960-61-3
(R,S)-(4-fluorophenyl)(2-methyl-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-pyrazolo[3,4-d]pyrimidin-6-yl)methanol acetate

Guidance literature:: 3-methyl-5-aminopyrazole; (4-chloro-2-methyl-2H-pyrazolo[3,4-d]pyrimidin-6-yl)(4-fluorophenyl)methanone; With triethylamine; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 ℃; for 1.5h;

acetic acid; In acetonitrile;

Reference yield:

: 21230-50-2
3-amino-1-methyl-1H-pyrazole-4-carbonitrile

: 1361960-61-3
(R,S)-(4-fluorophenyl)(2-methyl-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-pyrazolo[3,4-d]pyrimidin-6-yl)methanol acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 1 h / 0 - 20 °C

1.2: 0.17 h / 0 - 20 °C / pH 7 - 8

2.1: hydrogenchloride / water; acetic acid / 5 h / 100 °C

3.1: trichlorophosphate / 2 h / 85 °C

4.1: tetrahydrofuran / 1 h / -30 °C / Inert atmosphere

5.1: potassium iodide; triethylamine / N,N-dimethyl-formamide / 4 h / 20 °C

5.2: 1.5 h / 0 °C

With hydrogenchloride; sulfuric acid; triethylamine; potassium iodide; trichlorophosphate; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 89181-79-3
3-amino-1-methyl-1H-pyrazole-4-carboxamide

: 1361960-61-3
(R,S)-(4-fluorophenyl)(2-methyl-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-pyrazolo[3,4-d]pyrimidin-6-yl)methanol acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water; acetic acid / 5 h / 100 °C

2.1: trichlorophosphate / 2 h / 85 °C

3.1: tetrahydrofuran / 1 h / -30 °C / Inert atmosphere

4.1: potassium iodide; triethylamine / N,N-dimethyl-formamide / 4 h / 20 °C

4.2: 1.5 h / 0 °C

With hydrogenchloride; triethylamine; potassium iodide; trichlorophosphate; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide;