(S)-3-(1-benzyl-4-ethyl-1H-indol-7-yl)butyl methanesulfonate

Base Information

Chemical Name:(S)-3-(1-benzyl-4-ethyl-1H-indol-7-yl)butyl methanesulfonate
CAS No.:1443437-18-0
Molecular Formula:C₂₂H₂₇NO₃S
Molecular Weight:385.527
Hs Code.:

Synonyms:(S)-3-(1-benzyl-4-ethyl-1H-indol-7-yl)butyl methanesulfonate

Suppliers and Price of (S)-3-(1-benzyl-4-ethyl-1H-indol-7-yl)butyl methanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-3-(1-benzyl-4-ethyl-1H-indol-7-yl)butyl methanesulfonate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of (S)-3-(1-benzyl-4-ethyl-1H-indol-7-yl)butyl methanesulfonate

There total 9 articles about (S)-3-(1-benzyl-4-ethyl-1H-indol-7-yl)butyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1443437-17-9
(S)-3-(1-benzyl-4-ethyl-1H-indol-7-yl)butan-1-ol

: 124-63-0
methanesulfonyl chloride

: 1443437-18-0
(S)-3-(1-benzyl-4-ethyl-1H-indol-7-yl)butyl methanesulfonate

Guidance literature:: With pyridine; dmap; In dichloromethane; at 20 ℃; for 13h;
DOI:10.1002/chem.201202413

Reference yield:

: 18640-58-9
3-nitro-4-bromoacetophenone

: 1443437-18-0
(S)-3-(1-benzyl-4-ethyl-1H-indol-7-yl)butyl methanesulfonate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium tetrahydroborate / methanol / 0.5 h / 0 - 20 °C

2.1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 3 h / 0 °C

2.2: 0.5 h / 0 - 20 °C

3.1: tetrahydrofuran / 0.75 h / -45 °C / Schlenk technique; Inert atmosphere

4.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h

4.2: 12 h / 20 °C

5.1: palladium dichloride; triethylamine; tris-(o-tolyl)phosphine / acetonitrile / 15 h / 110 °C / Schlenk technique; Inert atmosphere

6.1: magnesium; methanol / 13 h / Reflux

7.1: Amano lipase PS-IM (immobilized on diatomaceous earth) / water; di-isopropyl ether / 65 h / 40 °C / Resolution of racemate; Enzymatic reaction

8.1: copper(I) bromide dimethylsulfide complex; methanol / diethyl ether / 5 h / 0 - 20 °C / Reflux

9.1: pyridine; dmap / dichloromethane / 13 h / 20 °C

With pyridine; 1H-imidazole; methanol; dmap; sodium tetrahydroborate; copper(I) bromide dimethylsulfide complex; Amano lipase PS-IM (immobilized on diatomaceous earth); iodine; magnesium; triethylamine; triphenylphosphine; tris-(o-tolyl)phosphine; potassium hydroxide; palladium dichloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; di-isopropyl ether; water; dimethyl sulfoxide; acetonitrile; 3.1: |Bartoli Indole Synthesis;
DOI:10.1002/chem.201202413

Reference yield:

: 161988-90-5
7-bromo-4-ethyl-1H-indole

: 1443437-18-0
(S)-3-(1-benzyl-4-ethyl-1H-indol-7-yl)butyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h

1.2: 12 h / 20 °C

2.1: palladium dichloride; triethylamine; tris-(o-tolyl)phosphine / acetonitrile / 15 h / 110 °C / Schlenk technique; Inert atmosphere

3.1: magnesium; methanol / 13 h / Reflux

4.1: Amano lipase PS-IM (immobilized on diatomaceous earth) / water; di-isopropyl ether / 65 h / 40 °C / Resolution of racemate; Enzymatic reaction

5.1: copper(I) bromide dimethylsulfide complex; methanol / diethyl ether / 5 h / 0 - 20 °C / Reflux

6.1: pyridine; dmap / dichloromethane / 13 h / 20 °C

With pyridine; methanol; dmap; copper(I) bromide dimethylsulfide complex; Amano lipase PS-IM (immobilized on diatomaceous earth); magnesium; triethylamine; tris-(o-tolyl)phosphine; potassium hydroxide; palladium dichloride; In diethyl ether; dichloromethane; di-isopropyl ether; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1002/chem.201202413