N-((9H-fluoren-2-yl)methyl)-4-(4-(2,3-dichlorophenyl)-piperazin-1-yl)-3-fluoro-N-methylbutan-1-amine

Base Information

Chemical Name:N-((9H-fluoren-2-yl)methyl)-4-(4-(2,3-dichlorophenyl)-piperazin-1-yl)-3-fluoro-N-methylbutan-1-amine
CAS No.:1301179-19-0
Molecular Formula:C₂₉H₃₂Cl₂FN₃
Molecular Weight:512.498
Hs Code.:

Synonyms:N-((9H-fluoren-2-yl)methyl)-4-(4-(2,3-dichlorophenyl)-piperazin-1-yl)-3-fluoro-N-methylbutan-1-amine

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Chemical Property of N-((9H-fluoren-2-yl)methyl)-4-(4-(2,3-dichlorophenyl)-piperazin-1-yl)-3-fluoro-N-methylbutan-1-amine

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Technology Process of N-((9H-fluoren-2-yl)methyl)-4-(4-(2,3-dichlorophenyl)-piperazin-1-yl)-3-fluoro-N-methylbutan-1-amine

There total 5 articles about N-((9H-fluoren-2-yl)methyl)-4-(4-(2,3-dichlorophenyl)-piperazin-1-yl)-3-fluoro-N-methylbutan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1301179-17-8
N-((9H-fluoren-2-yl)methyl)-4-(4-(2,3-dichlorophenyl)-piperazin-1-yl)-3-fluorobutan-1-amine

: 1301179-19-0
N-((9H-fluoren-2-yl)methyl)-4-(4-(2,3-dichlorophenyl)-piperazin-1-yl)-3-fluoro-N-methylbutan-1-amine

Guidance literature:: With sodium tris(acetoxy)borohydride; In water; 1,2-dichloro-ethane; at 20 ℃; for 12h;
DOI:10.1021/jm200288r

Reference yield:

: C₂₈H₂₈Cl₂FN₃

: 1301179-19-0
N-((9H-fluoren-2-yl)methyl)-4-(4-(2,3-dichlorophenyl)-piperazin-1-yl)-3-fluoro-N-methylbutan-1-amine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 0.5 h / Inert atmosphere

2: sodium tris(acetoxy)borohydride / water; 1,2-dichloro-ethane / 12 h / 20 °C

With sodium tetrahydroborate; sodium tris(acetoxy)borohydride; In methanol; water; 1,2-dichloro-ethane;
DOI:10.1021/jm200288r

Reference yield:

: 1301178-79-9
4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-fluorobutan-1-amine

: 1301179-19-0
N-((9H-fluoren-2-yl)methyl)-4-(4-(2,3-dichlorophenyl)-piperazin-1-yl)-3-fluoro-N-methylbutan-1-amine

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 12 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 0.5 h / Inert atmosphere

3: sodium tris(acetoxy)borohydride / water; 1,2-dichloro-ethane / 12 h / 20 °C

With sodium tetrahydroborate; sodium tris(acetoxy)borohydride; In methanol; water; 1,2-dichloro-ethane;
DOI:10.1021/jm200288r