Indolizine, 8-(fluoromethyl)octahydro-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

Base Information

Chemical Name:Indolizine, 8-(fluoromethyl)octahydro-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-
CAS No.:171925-39-6
Molecular Formula:C₃₀H₃₄FNO₃
Molecular Weight:475.603
Hs Code.:
Mol file:171925-39-6.mol

Synonyms:Indolizine, 8-(fluoromethyl)octahydro-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

Suppliers and Price of Indolizine, 8-(fluoromethyl)octahydro-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Indolizine, 8-(fluoromethyl)octahydro-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

Chemical Property:

Purity/Quality:

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Technology Process of Indolizine, 8-(fluoromethyl)octahydro-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

There total 10 articles about Indolizine, 8-(fluoromethyl)octahydro-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 171925-37-4
1,6,7-tri-O-benzyl-8-deoxy-8-C-hydroxymethylcastanospermine

: 171925-39-6
1,6,7-tri-O-benzyl-8-deoxy-8-C-fluoromethylcastanospermine

Guidance literature:: With 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1016/0040-4020(95)00803-G

Reference yield:

: 79831-76-8
(1S,6S,7R,8R,8aR)-2,6,7,8-tetrahydroxy-indolizidine

: 171925-39-6
1,6,7-tri-O-benzyl-8-deoxy-8-C-fluoromethylcastanospermine

Guidance literature:: Multi-step reaction with 7 steps

1: 1.)Bu₂SnO, 2.) Bu₄NBr, 3.) LiH, Pr-SH / 1.) MePh, reflux, 2 h, 2.) MePh, reflux, 3 days, 3.) DMSO, 3 h

2: Et₃N / CH₂Cl₂

3: dimethylsulfoxide / 1 h / 90 °C

4: NaH₂PO₂, Raney Ni / pyridine; acetic acid / Ambient temperature

5: TsOH / CH₂Cl₂; acetone / 0.33 h

6: NaBH₄ / methanol

7: 30 percent / DAST / CH₂Cl₂ / 4 h / Ambient temperature

With sodium tetrahydroborate; sodium hypophosphite; 1-thiopropane; tetrabutylammomium bromide; nickel; lithium hydride; di(n-butyl)tin oxide; toluene-4-sulfonic acid; triethylamine; 4,4'-diaminostilbene-2,2'-disulfonic acid; In pyridine; methanol; dichloromethane; acetic acid; dimethyl sulfoxide; acetone;
DOI:10.1016/0040-4020(95)00803-G

Reference yield:

: 100-39-0
benzyl bromide

: 171925-39-6
1,6,7-tri-O-benzyl-8-deoxy-8-C-fluoromethylcastanospermine

Guidance literature:: Multi-step reaction with 7 steps

1: 1.)Bu₂SnO, 2.) Bu₄NBr, 3.) LiH, Pr-SH / 1.) MePh, reflux, 2 h, 2.) MePh, reflux, 3 days, 3.) DMSO, 3 h

2: Et₃N / CH₂Cl₂

3: dimethylsulfoxide / 1 h / 90 °C

4: NaH₂PO₂, Raney Ni / pyridine; acetic acid / Ambient temperature

5: TsOH / CH₂Cl₂; acetone / 0.33 h

6: NaBH₄ / methanol

7: 30 percent / DAST / CH₂Cl₂ / 4 h / Ambient temperature

With sodium tetrahydroborate; sodium hypophosphite; 1-thiopropane; tetrabutylammomium bromide; nickel; lithium hydride; di(n-butyl)tin oxide; toluene-4-sulfonic acid; triethylamine; 4,4'-diaminostilbene-2,2'-disulfonic acid; In pyridine; methanol; dichloromethane; acetic acid; dimethyl sulfoxide; acetone;
DOI:10.1016/0040-4020(95)00803-G