1-{2-[[2-(2-tert-butoxycarbonylamino-8-oxo-decanoylamino)-3-(1H-indol-3-yl)-propyl]-(2-nitro-benzenesulfonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

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Chemical Name:1-{2-[[2-(2-tert-butoxycarbonylamino-8-oxo-decanoylamino)-3-(1H-indol-3-yl)-propyl]-(2-nitro-benzenesulfonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester
CAS No.:288074-34-0
Molecular Formula:C₄₇H₆₈N₆O₁₁S
Molecular Weight:925.157
Hs Code.:

1-{2-[[2-(2-<i>tert</i>-butoxycarbonylamino-8-oxo-decanoylamino)-3-(1<i>H</i>-indol-3-yl)-propyl]-(2-nitro-benzenesulfonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid <i>tert</i>-butyl ester

Synonyms:1-{2-[[2-(2-tert-butoxycarbonylamino-8-oxo-decanoylamino)-3-(1H-indol-3-yl)-propyl]-(2-nitro-benzenesulfonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

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Chemical Property of 1-{2-[[2-(2-tert-butoxycarbonylamino-8-oxo-decanoylamino)-3-(1H-indol-3-yl)-propyl]-(2-nitro-benzenesulfonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

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Technology Process of 1-{2-[[2-(2-tert-butoxycarbonylamino-8-oxo-decanoylamino)-3-(1H-indol-3-yl)-propyl]-(2-nitro-benzenesulfonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

There total 15 articles about 1-{2-[[2-(2-tert-butoxycarbonylamino-8-oxo-decanoylamino)-3-(1H-indol-3-yl)-propyl]-(2-nitro-benzenesulfonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 335637-29-1
(2S)-2-{[(tert-butoxy)carbonyl]amino}-8-oxodecanoic acid

: 288074-33-9
(R)-1-{(2S,3S)-2-[[(S)-2-Amino-3-(1H-indol-3-yl)-propyl]-(2-nitro-benzenesulfonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

: 288074-34-0
1-{2-[[2-(2-tert-butoxycarbonylamino-8-oxo-decanoylamino)-3-(1H-indol-3-yl)-propyl]-(2-nitro-benzenesulfonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1016/S0960-894X(01)00049-X

Reference yield:

: 95715-87-0
(R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine

: 288074-34-0
1-{2-[[2-(2-tert-butoxycarbonylamino-8-oxo-decanoylamino)-3-(1H-indol-3-yl)-propyl]-(2-nitro-benzenesulfonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 88 percent / LiHMDS / tetrahydrofuran / 1 h / 15 - 20 °C

2.1: 100 percent / H₂ / Pd/C / ethanol / 1.5 h / 20 °C

3.1: 66 percent / TBTU; Et₃N / CH₂Cl₂ / 2 h / 20 °C

4.1: diethyl ether; tetrahydrofuran / 6 h / 0 - 20 °C

4.2: 89 percent / Amberlyst-15 resin / methanol / 96 h / 20 °C

5.1: 65 percent / PDC; 4 Angstroem sieves / dimethylformamide / 4 h / 20 °C

6.1: 65 percent / TBTU; HOBt; DIPEA / CH₂Cl₂; dimethylformamide / 3 h / 20 °C

With dipyridinium dichromate; 4 A molecular sieve; hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00049-X

Reference yield:

: 17814-85-6
(4-carboxybutyl)triphenylphosphonium bromide

: 288074-34-0
1-{2-[[2-(2-tert-butoxycarbonylamino-8-oxo-decanoylamino)-3-(1H-indol-3-yl)-propyl]-(2-nitro-benzenesulfonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 88 percent / LiHMDS / tetrahydrofuran / 1 h / 15 - 20 °C

2.1: 100 percent / H₂ / Pd/C / ethanol / 1.5 h / 20 °C

3.1: 66 percent / TBTU; Et₃N / CH₂Cl₂ / 2 h / 20 °C

4.1: diethyl ether; tetrahydrofuran / 6 h / 0 - 20 °C

4.2: 89 percent / Amberlyst-15 resin / methanol / 96 h / 20 °C

5.1: 65 percent / PDC; 4 Angstroem sieves / dimethylformamide / 4 h / 20 °C

6.1: 65 percent / TBTU; HOBt; DIPEA / CH₂Cl₂; dimethylformamide / 3 h / 20 °C

With dipyridinium dichromate; 4 A molecular sieve; hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00049-X