C₃₉H₃₇N₃O₂

Base Information

• Chemical Name: C₃₉H₃₇N₃O₂
• CAS No.: 1442686-76-1
• Molecular Formula: C₃₉H₃₇N₃O₂
• Molecular Weight: 579.742
• Mol file: 1442686-76-1.mol

Synonyms:C₃₉H₃₇N₃O₂

Chemical Property of C₃₉H₃₇N₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₉H₃₇N₃O₂

There total 7 articles about C₃₉H₃₇N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(3aS,8aS)-hexahydro-2,2-dimethyl-4,4,8,8-tetraphenyl-6H-1,3-dioxolo[4,5-e][1,3]diazepine-6-thione (1399830-18-2) + benzylamine (100-46-9) → C39H37N3O2 (1442686-76-1)

Guidance literature:

(3aS,8aS)-hexahydro-2,2-dimethyl-4,4,8,8-tetraphenyl-6H-1,3-dioxolo[4,5-e][1,3]diazepine-6-thione; With potassium carbonate; copper(l) chloride; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

benzylamine; In tetrahydrofuran; at 40 ℃;

DOI:10.1021/acs.orglett.5b02470

Reference yield:

(4S,5S)-2,2-dimethyl-α,α,α',α'-tetraphenyl-1,3-dioxolane-4,5-dimethanamine (147700-75-2) → C39H37N3O2 (1442686-76-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine / 7 h / 60 °C / Inert atmosphere

2.1: copper(l) chloride; potassium carbonate / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

2.2: 40 °C / Inert atmosphere

3.1: sodium hydroxide / dichloromethane; water / 2 h / Inert atmosphere

With potassium carbonate; copper(l) chloride; sodium hydroxide; In tetrahydrofuran; pyridine; dichloromethane; water;

DOI:10.1021/ol401306h

Reference yield:

2,2-dimethoxy-propane (77-76-9) → C39H37N3O2 (1442686-76-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / benzene / 8 h / Reflux; Inert atmosphere; Dean-Stark

2.1: magnesium / tetrahydrofuran / Cooling with ice; Inert atmosphere

2.2: 1.5 h / Reflux

3.1: thionyl chloride; triethylamine / dichloromethane / 3 h / Reflux; Inert atmosphere

3.2: 72 h / 80 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere

5.1: pyridine / 7 h / 60 °C / Inert atmosphere

6.1: copper(l) chloride; potassium carbonate / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

6.2: 40 °C / Inert atmosphere

7.1: sodium hydroxide / dichloromethane; water / 2 h / Inert atmosphere

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; toluene-4-sulfonic acid; magnesium; triethylamine; copper(l) chloride; sodium hydroxide; In tetrahydrofuran; pyridine; dichloromethane; water; benzene;

DOI:10.1021/ol401306h

upstream raw materials:

(4S,5S)-2,2-dimethyl-α,α,α',α'-tetraphenyl-1,3-dioxolane-4,5-dimethanamine

2,2-dimethoxy-propane

bromobenzene

(-)-dimethy-2,3-O-isopropylidene-L-tartrate