ethyl 2-amino-4-(4-chlorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 2,2,2-trifluoroacetate

Base Information

Chemical Name:ethyl 2-amino-4-(4-chlorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 2,2,2-trifluoroacetate
CAS No.:1449242-18-5
Molecular Formula:C₂HF₃O₂*C₁₄H₁₆ClN₃O₂
Molecular Weight:407.777
Hs Code.:

Synonyms:ethyl 2-amino-4-(4-chlorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 2,2,2-trifluoroacetate

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Chemical Property of ethyl 2-amino-4-(4-chlorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 2,2,2-trifluoroacetate

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Technology Process of ethyl 2-amino-4-(4-chlorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 2,2,2-trifluoroacetate

There total 2 articles about ethyl 2-amino-4-(4-chlorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1449242-16-3
ethyl 2-amino-4-(4-chlorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate

: 76-05-1
trifluoroacetic acid

: 1449242-18-5
ethyl 2-amino-4-(4-chlorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 2,2,2-trifluoroacetate

Guidance literature:: With triethylsilane; methyl-phenyl-thioether; In water; at 50 ℃; for 22h;
DOI:10.1016/j.tet.2013.04.127

Reference yield:

: 19411-80-4
2-(4-chlorophenylmethylene)acetoacetic acid ethyl ester

: 1449242-18-5
ethyl 2-amino-4-(4-chlorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1,1,3',3',3'-hexafluoro-propanol; sodium hydrogencarbonate / 16 h / 90 °C / Sealed tube

2: triethylsilane; methyl-phenyl-thioether / water / 22 h / 50 °C

With triethylsilane; 1,1,1,3',3',3'-hexafluoro-propanol; methyl-phenyl-thioether; sodium hydrogencarbonate; In water;
DOI:10.1016/j.tet.2013.04.127

Reference yield: 57.0%

: 1449242-18-5
ethyl 2-amino-4-(4-chlorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 2,2,2-trifluoroacetate

: 19411-80-4
2-(4-chlorophenylmethylene)acetoacetic acid ethyl ester

: diethyl 4,6-bis(4-chlorophenyl)-2,8-dimethyl-4,6-dihydro-1H-pyrimido[1,2-a]pyrimidine-3,7-dicarboxylate

Guidance literature:: With 1,1,1,3',3',3'-hexafluoro-propanol; sodium hydrogencarbonate; at 90 ℃; for 42h; Sealed tube;
DOI:10.1016/j.tet.2013.04.127