[(S)-4-(4-Methoxy-benzyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2-(2-methoxy-ethoxymethoxy)-phenyl]-methanone

Base Information

Chemical Name:[(S)-4-(4-Methoxy-benzyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2-(2-methoxy-ethoxymethoxy)-phenyl]-methanone
CAS No.:205505-75-5
Molecular Formula:C₂₄H₃₀O₇
Molecular Weight:430.498
Hs Code.:

Synonyms:[(S)-4-(4-Methoxy-benzyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2-(2-methoxy-ethoxymethoxy)-phenyl]-methanone

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Chemical Property of [(S)-4-(4-Methoxy-benzyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2-(2-methoxy-ethoxymethoxy)-phenyl]-methanone

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Technology Process of [(S)-4-(4-Methoxy-benzyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2-(2-methoxy-ethoxymethoxy)-phenyl]-methanone

There total 6 articles about [(S)-4-(4-Methoxy-benzyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2-(2-methoxy-ethoxymethoxy)-phenyl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20566-48-7
2-[(4-methoxyphenyl)methyl]acrylic acid ethyl ester

: 205505-75-5
[(S)-4-(4-Methoxy-benzyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2-(2-methoxy-ethoxymethoxy)-phenyl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: AD-mix-β <(DHQD)2PHAL> / 2-methyl-propan-2-ol; H2O / 24 h / 0 °C

2: 83 percent / p-TsOH / tetrahydrofuran / Ambient temperature

3: 88 percent / DIBALH / toluene / 0.5 h / -78 °C

4: 1.) n-BuLi; 2.) pyridiniumchlorochromate, NaOAc / 1.) THF, -78 deg C to r.t.; 2.) CH₂Cl₂, reflux

With n-butyllithium; sodium acetate; diisobutylaluminium hydride; toluene-4-sulfonic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; pyridinium chlorochromate; In tetrahydrofuran; water; toluene; tert-butyl alcohol;
DOI:10.3987/COM-97-S24

Reference yield:

: 205505-50-6
3-ethoxy-2-(4-methoxybenzyl)-3-oxopropanoic acid

: 205505-75-5
[(S)-4-(4-Methoxy-benzyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2-(2-methoxy-ethoxymethoxy)-phenyl]-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / NaH / tetrahydrofuran / Heating

2: AD-mix-β <(DHQD)2PHAL> / 2-methyl-propan-2-ol; H2O / 24 h / 0 °C

3: 83 percent / p-TsOH / tetrahydrofuran / Ambient temperature

4: 88 percent / DIBALH / toluene / 0.5 h / -78 °C

5: 1.) n-BuLi; 2.) pyridiniumchlorochromate, NaOAc / 1.) THF, -78 deg C to r.t.; 2.) CH₂Cl₂, reflux

With n-butyllithium; sodium acetate; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; pyridinium chlorochromate; In tetrahydrofuran; water; toluene; tert-butyl alcohol;
DOI:10.3987/COM-97-S24

Reference yield:

: 205505-64-2
(S)-4-(4-Methoxy-benzyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid ethyl ester

: 205505-75-5
[(S)-4-(4-Methoxy-benzyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2-(2-methoxy-ethoxymethoxy)-phenyl]-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / DIBALH / toluene / 0.5 h / -78 °C

2: 1.) n-BuLi; 2.) pyridiniumchlorochromate, NaOAc / 1.) THF, -78 deg C to r.t.; 2.) CH₂Cl₂, reflux

With n-butyllithium; sodium acetate; diisobutylaluminium hydride; pyridinium chlorochromate; In toluene;
DOI:10.3987/COM-97-S24