(+/-)-2-(2,3-dimethoxybenzyl)-6-hydroxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(+/-)-2-(2,3-dimethoxybenzyl)-6-hydroxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:1602588-99-7
Molecular Formula:C₂₀H₂₅NO₄
Molecular Weight:343.423
Hs Code.:

Synonyms:(+/-)-2-(2,3-dimethoxybenzyl)-6-hydroxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of (+/-)-2-(2,3-dimethoxybenzyl)-6-hydroxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-2-(2,3-dimethoxybenzyl)-6-hydroxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of (+/-)-2-(2,3-dimethoxybenzyl)-6-hydroxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

There total 10 articles about (+/-)-2-(2,3-dimethoxybenzyl)-6-hydroxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1602588-74-8
(+/-)-2-(2,3-dimethoxybenzyl)-7-methoxy-3-methyl-6-(triisopropylsilyloxy)-1,2,3,4-tetrahydroisoquinoline

: 1602588-99-7
(+/-)-2-(2,3-dimethoxybenzyl)-6-hydroxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1002/cmdc.201300412

Reference yield:

: 1064202-11-4
(+/-)-6-benzyloxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

: 1602588-99-7
(+/-)-2-(2,3-dimethoxybenzyl)-6-hydroxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / methanol / 24 h / 20 °C

2: dichloromethane / 22 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 80 °C / Microwave irradiation

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

With tetrabutyl ammonium fluoride; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300412

Reference yield:

: 6346-05-0
3-benzyloxy-4-methoxybenzaldehyde

: 1602588-99-7
(+/-)-2-(2,3-dimethoxybenzyl)-6-hydroxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 10 steps

1: ammonium acetate / 22 h / 120 °C

2: sodium tetrahydroborate / ethanol; tetrahydrofuran / 2 h / 0 - 20 °C

3: nickel; hydrazine hydrate / methanol / 18 h / 0 - 40 °C

4: triethylamine; acetic anhydride / dichloromethane / 23 h / 0 °C

5: toluene-4-sulfonic acid / toluene / 22 h / 120 °C

6: potassium hydroxide / ethanol; water / 66 h / 120 °C

7: hydrogen / methanol / 24 h / 20 °C

8: dichloromethane / 22 h / 20 °C

9: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 80 °C / Microwave irradiation

10: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

With sodium tetrahydroborate; ammonium acetate; tetrabutyl ammonium fluoride; hydrogen; acetic anhydride; nickel; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201300412