Technology Process of (+/-)-2-(2,3-dimethoxybenzyl)-7-methoxy-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline
There total 11 articles about (+/-)-2-(2,3-dimethoxybenzyl)-7-methoxy-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sulphamoyl chloride;
In
N,N-dimethyl acetamide;
at 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1002/cmdc.201300412
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrogen / methanol / 24 h / 20 °C
2: dichloromethane / 22 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 80 °C / Microwave irradiation
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C
5: sulphamoyl chloride / N,N-dimethyl acetamide / 2 h / 20 °C / Inert atmosphere
With
sulphamoyl chloride; tetrabutyl ammonium fluoride; hydrogen; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300412
- Guidance literature:
-
Multi-step reaction with 11 steps
1: ammonium acetate / 22 h / 120 °C
2: sodium tetrahydroborate / ethanol; tetrahydrofuran / 2 h / 0 - 20 °C
3: nickel; hydrazine hydrate / methanol / 18 h / 0 - 40 °C
4: triethylamine; acetic anhydride / dichloromethane / 23 h / 0 °C
5: toluene-4-sulfonic acid / toluene / 22 h / 120 °C
6: potassium hydroxide / ethanol; water / 66 h / 120 °C
7: hydrogen / methanol / 24 h / 20 °C
8: dichloromethane / 22 h / 20 °C
9: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 80 °C / Microwave irradiation
10: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C
11: sulphamoyl chloride / N,N-dimethyl acetamide / 2 h / 20 °C / Inert atmosphere
With
sodium tetrahydroborate; sulphamoyl chloride; ammonium acetate; tetrabutyl ammonium fluoride; hydrogen; acetic anhydride; nickel; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201300412
