(Z)-2-((7-fluorofuro[3,4-b]quinolin-3(1H)-ylidene)methyl)isophthalonitrile

Base Information

Chemical Name:(Z)-2-((7-fluorofuro[3,4-b]quinolin-3(1H)-ylidene)methyl)isophthalonitrile
CAS No.:1315508-76-9
Molecular Formula:C₂₀H₁₀FN₃O
Molecular Weight:327.317
Hs Code.:

Synonyms:(Z)-2-((7-fluorofuro[3,4-b]quinolin-3(1H)-ylidene)methyl)isophthalonitrile

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Chemical Property of (Z)-2-((7-fluorofuro[3,4-b]quinolin-3(1H)-ylidene)methyl)isophthalonitrile

Chemical Property:

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Technology Process of (Z)-2-((7-fluorofuro[3,4-b]quinolin-3(1H)-ylidene)methyl)isophthalonitrile

There total 5 articles about (Z)-2-((7-fluorofuro[3,4-b]quinolin-3(1H)-ylidene)methyl)isophthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1315508-65-6
(Z)-3-(2,6-dicyanophenyl)-N-(4-fluorophenyl)-2-(prop-2-ynyloxy)acrylamide

: 1315508-76-9
(Z)-2-((7-fluorofuro[3,4-b]quinolin-3(1H)-ylidene)methyl)isophthalonitrile

Guidance literature:: With trifluoromethylsulfonic anhydride; Triphenylphosphine oxide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.05.067

Reference yield:

: 1315508-58-7
(Z)-3-(2,6-dicyanophenyl)-2-(prop-2-ynyloxy)acrylic acid

: 1315508-76-9
(Z)-2-((7-fluorofuro[3,4-b]quinolin-3(1H)-ylidene)methyl)isophthalonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 °C / Inert atmosphere

2: sodium hydrogencarbonate / dichloromethane / 1 h / Inert atmosphere

3: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / dichloromethane / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; trifluoromethylsulfonic anhydride; sodium hydrogencarbonate; N,N-dimethyl-formamide; Triphenylphosphine oxide; In dichloromethane;
DOI:10.1016/j.tet.2011.05.067

Reference yield:

: C₁₃H₁₀N₂O₃

: 1315508-76-9
(Z)-2-((7-fluorofuro[3,4-b]quinolin-3(1H)-ylidene)methyl)isophthalonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: tributylphosphine; diethylazodicarboxylate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere

2.2: pH 4 - 5

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / dichloromethane / 1 h / Inert atmosphere

5.1: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / dichloromethane / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; lithium hydroxide monohydrate; tributylphosphine; trifluoromethylsulfonic anhydride; sodium hydrogencarbonate; N,N-dimethyl-formamide; Triphenylphosphine oxide; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; 1.1: Mitsunobu reaction;
DOI:10.1016/j.tet.2011.05.067