(Z)-3-(2,6-dicyanophenyl)-N-(4-fluorophenyl)-2-(prop-2-ynyloxy)acrylamide

Base Information

Chemical Name:(Z)-3-(2,6-dicyanophenyl)-N-(4-fluorophenyl)-2-(prop-2-ynyloxy)acrylamide
CAS No.:1315508-65-6
Molecular Formula:C₂₀H₁₂FN₃O₂
Molecular Weight:345.333
Hs Code.:

Synonyms:(Z)-3-(2,6-dicyanophenyl)-N-(4-fluorophenyl)-2-(prop-2-ynyloxy)acrylamide

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Chemical Property of (Z)-3-(2,6-dicyanophenyl)-N-(4-fluorophenyl)-2-(prop-2-ynyloxy)acrylamide

Chemical Property:

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Technology Process of (Z)-3-(2,6-dicyanophenyl)-N-(4-fluorophenyl)-2-(prop-2-ynyloxy)acrylamide

There total 5 articles about (Z)-3-(2,6-dicyanophenyl)-N-(4-fluorophenyl)-2-(prop-2-ynyloxy)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₇ClN₂O₂

: 371-40-4
4-fluoroaniline

: 1315508-65-6
(Z)-3-(2,6-dicyanophenyl)-N-(4-fluorophenyl)-2-(prop-2-ynyloxy)acrylamide

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2011.05.067

Reference yield:

: 1315508-58-7
(Z)-3-(2,6-dicyanophenyl)-2-(prop-2-ynyloxy)acrylic acid

: 1315508-65-6
(Z)-3-(2,6-dicyanophenyl)-N-(4-fluorophenyl)-2-(prop-2-ynyloxy)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 °C / Inert atmosphere

2: sodium hydrogencarbonate / dichloromethane / 1 h / Inert atmosphere

With oxalyl dichloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1016/j.tet.2011.05.067

Reference yield:

: C₁₃H₁₀N₂O₃

: 1315508-65-6
(Z)-3-(2,6-dicyanophenyl)-N-(4-fluorophenyl)-2-(prop-2-ynyloxy)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tributylphosphine; diethylazodicarboxylate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere

2.2: pH 4 - 5

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / dichloromethane / 1 h / Inert atmosphere

With oxalyl dichloride; lithium hydroxide monohydrate; tributylphosphine; sodium hydrogencarbonate; N,N-dimethyl-formamide; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; 1.1: Mitsunobu reaction;
DOI:10.1016/j.tet.2011.05.067