1-<4-(methoxymethoxy)phenyl>-6-hydroxy-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester

Base Information

• Chemical Name: 1-<4-(methoxymethoxy)phenyl>-6-hydroxy-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester
• CAS No.: 128550-17-4
• Molecular Formula: C₄₅H₈₀N₆O₁₂
• Molecular Weight: 897.163
• Mol file: 128550-17-4.mol

Synonyms:1-<4-(methoxymethoxy)phenyl>-6-hydroxy-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester

Chemical Property of 1-<4-(methoxymethoxy)phenyl>-6-hydroxy-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<4-(methoxymethoxy)phenyl>-6-hydroxy-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester

There total 11 articles about 1-<4-(methoxymethoxy)phenyl>-6-hydroxy-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 1-<4-(methoxymethoxy)phenyl>-6-hydroxy-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester (128550-17-4)

Guidance literature:

Multi-step reaction with 9 steps

1: 96 percent / CH₂Cl₂ / 68 h / Ambient temperature

2: 95 percent / H₂ / Pd(OH)2/C / acetic acid / 2 h / 2585.7 Torr

3: 100 percent / methanol / 12 h / Ambient temperature

4: 85 percent / CH₂Cl₂ / 1.5 h / Ambient temperature

5: H₂ / Pd(OH)2/C / acetic acid / 2 h / 2585.7 Torr

6: methanol / 12 h / Ambient temperature

7: H₂ / Pd(OH)2/C / acetic acid / 2 h / 2585.7 Torr

8: 1.) N-hydroxysuccinimide, dicyclohexylcarbodiimide (DCC) / 1.) CH₂Cl₂, 5 h, 2.) 72 h

9: 1.) 2-(phenylsulfonyl)-3-phenyloxaziridine, 2.) NaBH₃CN / 1.) CH₂Cl₂, 30 min, 2.) acetic acid, 3 h

With 1-hydroxy-pyrrolidine-2,5-dione; hydrogen; sodium cyanoborohydride; N-(benzenesulfonyl)-3-phenyloxaziridine; dicyclohexyl-carbodiimide; palladium dihydroxide; In methanol; dichloromethane; acetic acid;

Reference yield:

3-bromopropylamine tert-butylcarbamate (83948-53-2) → 1-<4-(methoxymethoxy)phenyl>-6-hydroxy-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester (128550-17-4)

Guidance literature:

Multi-step reaction with 10 steps

1: 60 percent / KF/Celite / acetonitrile / 1.) RT, 16 h, 2.) 70 deg C, 24 h

2: 96 percent / CH₂Cl₂ / 68 h / Ambient temperature

3: 95 percent / H₂ / Pd(OH)2/C / acetic acid / 2 h / 2585.7 Torr

4: 100 percent / methanol / 12 h / Ambient temperature

5: 85 percent / CH₂Cl₂ / 1.5 h / Ambient temperature

6: H₂ / Pd(OH)2/C / acetic acid / 2 h / 2585.7 Torr

7: methanol / 12 h / Ambient temperature

8: H₂ / Pd(OH)2/C / acetic acid / 2 h / 2585.7 Torr

9: 1.) N-hydroxysuccinimide, dicyclohexylcarbodiimide (DCC) / 1.) CH₂Cl₂, 5 h, 2.) 72 h

10: 1.) 2-(phenylsulfonyl)-3-phenyloxaziridine, 2.) NaBH₃CN / 1.) CH₂Cl₂, 30 min, 2.) acetic acid, 3 h

With potassium fluoride; 1-hydroxy-pyrrolidine-2,5-dione; Celite; hydrogen; sodium cyanoborohydride; N-(benzenesulfonyl)-3-phenyloxaziridine; dicyclohexyl-carbodiimide; palladium dihydroxide; In methanol; dichloromethane; acetic acid; acetonitrile;

Reference yield:

16-cyano-2,2-dimethyl-3-oxa-4-oxo-5,9,14-triazahexadecane (128550-02-7) → 1-<4-(methoxymethoxy)phenyl>-6-hydroxy-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester (128550-17-4)

Guidance literature:

Multi-step reaction with 9 steps

1: 96 percent / CH₂Cl₂ / 68 h / Ambient temperature

2: 95 percent / H₂ / Pd(OH)2/C / acetic acid / 2 h / 2585.7 Torr

3: 100 percent / methanol / 12 h / Ambient temperature

4: 85 percent / CH₂Cl₂ / 1.5 h / Ambient temperature

5: H₂ / Pd(OH)2/C / acetic acid / 2 h / 2585.7 Torr

6: methanol / 12 h / Ambient temperature

7: H₂ / Pd(OH)2/C / acetic acid / 2 h / 2585.7 Torr

8: 1.) N-hydroxysuccinimide, dicyclohexylcarbodiimide (DCC) / 1.) CH₂Cl₂, 5 h, 2.) 72 h

9: 1.) 2-(phenylsulfonyl)-3-phenyloxaziridine, 2.) NaBH₃CN / 1.) CH₂Cl₂, 30 min, 2.) acetic acid, 3 h

With 1-hydroxy-pyrrolidine-2,5-dione; hydrogen; sodium cyanoborohydride; N-(benzenesulfonyl)-3-phenyloxaziridine; dicyclohexyl-carbodiimide; palladium dihydroxide; In methanol; dichloromethane; acetic acid;

upstream raw materials:

1-<4-(methoxymethoxy)phenyl>-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester

di-tert-butyl dicarbonate

3-bromopropylamine tert-butylcarbamate

16-cyano-2,2-dimethyl-3-oxa-4-oxo-5,9,14-triazahexadecane

Downstream raw materials:

N-(20-amino-4-hydroxy-4,8,12,17-tetraazaeicos-1-yl)-4-hydroxybenzamide