1-benzyl-3-(3,5-dichloro-2-fluorophenyl)-3-(trifluoromethyl)pyrrolidine

Base Information

Chemical Name:1-benzyl-3-(3,5-dichloro-2-fluorophenyl)-3-(trifluoromethyl)pyrrolidine
CAS No.:1364674-31-6
Molecular Formula:C₁₈H₁₅Cl₂F₄N
Molecular Weight:392.223
Hs Code.:

Synonyms:1-benzyl-3-(3,5-dichloro-2-fluorophenyl)-3-(trifluoromethyl)pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-benzyl-3-(3,5-dichloro-2-fluorophenyl)-3-(trifluoromethyl)pyrrolidine

Chemical Property:

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Technology Process of 1-benzyl-3-(3,5-dichloro-2-fluorophenyl)-3-(trifluoromethyl)pyrrolidine

There total 2 articles about 1-benzyl-3-(3,5-dichloro-2-fluorophenyl)-3-(trifluoromethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364674-30-5
1,5-dichloro-2-fluoro-3-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 93102-05-7
N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine

: 1364674-31-6
1-benzyl-3-(3,5-dichloro-2-fluorophenyl)-3-(trifluoromethyl)pyrrolidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield:

: 1160573-64-7
1-bromo-3,5-dichloro-2-fluorobenzene

: 1364674-31-6
1-benzyl-3-(3,5-dichloro-2-fluorophenyl)-3-(trifluoromethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2: trifluoroacetic acid / dichloromethane / 20 °C / Cooling with ice

With potassium carbonate; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1364674-31-6
1-benzyl-3-(3,5-dichloro-2-fluorophenyl)-3-(trifluoromethyl)pyrrolidine

: 3-(3,5-dichloro-4-fluoro-phenyl)-3-trifluoromethyl-pyrrolidine

Guidance literature:: 1-benzyl-3-(3,5-dichloro-2-fluorophenyl)-3-(trifluoromethyl)pyrrolidine; With isopropyl chloroformate; In 1,2-dichloro-ethane; at 20 ℃; for 3h; Reflux;

With methanol; for 2h; Reflux;