N-{4-[3-(3,5-dichloro-2-fluorophenyl)-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl]-(trifluoromethyl)benzyl}cyclopropanecarboxamide

Base Information

Chemical Name:N-{4-[3-(3,5-dichloro-2-fluorophenyl)-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl]-(trifluoromethyl)benzyl}cyclopropanecarboxamide
CAS No.:1364674-35-0
Molecular Formula:C₂₃H₁₉Cl₂F₇N₂O₂
Molecular Weight:559.311
Hs Code.:

Synonyms:N-{4-[3-(3,5-dichloro-2-fluorophenyl)-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl]-(trifluoromethyl)benzyl}cyclopropanecarboxamide

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Chemical Property of N-{4-[3-(3,5-dichloro-2-fluorophenyl)-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl]-(trifluoromethyl)benzyl}cyclopropanecarboxamide

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Technology Process of N-{4-[3-(3,5-dichloro-2-fluorophenyl)-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl]-(trifluoromethyl)benzyl}cyclopropanecarboxamide

There total 6 articles about N-{4-[3-(3,5-dichloro-2-fluorophenyl)-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl]-(trifluoromethyl)benzyl}cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364674-34-9
N-{4-[3-(3,5-dichloro-2-fluorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)benzyl}cyclopropanecarboxamide

: 1364674-35-0
N-{4-[3-(3,5-dichloro-2-fluorophenyl)-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl]-(trifluoromethyl)benzyl}cyclopropanecarboxamide

Guidance literature:: With ammonium cerium (IV) nitrate; In water; N,N-dimethyl-formamide; for 0.0333333h; Cooling with ice;

Reference yield:

: 1160573-64-7
1-bromo-3,5-dichloro-2-fluorobenzene

: 1364674-35-0
N-{4-[3-(3,5-dichloro-2-fluorophenyl)-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl]-(trifluoromethyl)benzyl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2.1: trifluoroacetic acid / dichloromethane / 20 °C / Cooling with ice

3.1: isopropyl chloroformate / 1,2-dichloro-ethane / 3 h / 20 °C / Reflux

3.2: 2 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 1 h / 20 °C / microwave reactor

5.1: sodium tetrahydroborate; 3-azapentane-1,5-diamine; methanol; nickel(II) chloride hexahydrate / 1,4-dioxane / 20 °C / Cooling with ice

6.1: ammonium cerium (IV) nitrate / N,N-dimethyl-formamide; water / 0.03 h / Cooling with ice

With methanol; sodium tetrahydroborate; ammonium cerium (IV) nitrate; nickel(II) chloride hexahydrate; potassium carbonate; isopropyl chloroformate; N-ethyl-N,N-diisopropylamine; 3-azapentane-1,5-diamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ISOPROPYLAMIDE; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1364674-30-5
1,5-dichloro-2-fluoro-3-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 1364674-35-0
N-{4-[3-(3,5-dichloro-2-fluorophenyl)-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl]-(trifluoromethyl)benzyl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C / Cooling with ice

2.1: isopropyl chloroformate / 1,2-dichloro-ethane / 3 h / 20 °C / Reflux

2.2: 2 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 1 h / 20 °C / microwave reactor

4.1: sodium tetrahydroborate; 3-azapentane-1,5-diamine; methanol; nickel(II) chloride hexahydrate / 1,4-dioxane / 20 °C / Cooling with ice

5.1: ammonium cerium (IV) nitrate / N,N-dimethyl-formamide; water / 0.03 h / Cooling with ice

With methanol; sodium tetrahydroborate; ammonium cerium (IV) nitrate; nickel(II) chloride hexahydrate; isopropyl chloroformate; N-ethyl-N,N-diisopropylamine; 3-azapentane-1,5-diamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; ISOPROPYLAMIDE; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;