1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-4,5-dimethyl-1,3-dihydro-2H-imidazole-2-thione

Base Information

Chemical Name:1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-4,5-dimethyl-1,3-dihydro-2H-imidazole-2-thione
CAS No.:1453114-84-5
Molecular Formula:C₁₇H₂₃N₃S
Molecular Weight:301.456
Hs Code.:

Synonyms:1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-4,5-dimethyl-1,3-dihydro-2H-imidazole-2-thione

Suppliers and Price of 1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-4,5-dimethyl-1,3-dihydro-2H-imidazole-2-thione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-4,5-dimethyl-1,3-dihydro-2H-imidazole-2-thione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-4,5-dimethyl-1,3-dihydro-2H-imidazole-2-thione

There total 8 articles about 1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-4,5-dimethyl-1,3-dihydro-2H-imidazole-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1453114-72-1
1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-4,5-dimethyl-1H-imidazole 3-oxide

: 1453114-84-5
1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-4,5-dimethyl-1,3-dihydro-2H-imidazole-2-thione

Guidance literature:: With 2,2,4,4-tetramethylcyclobutane-1,3-dithione; In chloroform; at 0 - 20 ℃;
DOI:10.1016/j.tetasy.2013.07.013

Reference yield:

: 31795-93-4
N-benzyl-L-proline

: 1453114-84-5
1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-4,5-dimethyl-1,3-dihydro-2H-imidazole-2-thione

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 8.17 h / Reflux

3.1: hydrazine / ethanol / 2 h / Reflux

3.2: 0.5 h / Heating

4.1: methanol / 20 °C

5.1: ethanol / 3 h / Reflux

6.1: 2,2,4,4-tetramethylcyclobutane-1,3-dithione / chloroform / 0 - 20 °C

With lithium aluminium tetrahydride; 2,2,4,4-tetramethylcyclobutane-1,3-dithione; triphenylphosphine; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; chloroform;
DOI:10.1016/j.tetasy.2013.07.013

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 1453114-84-5
1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-4,5-dimethyl-1,3-dihydro-2H-imidazole-2-thione

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide / isopropyl alcohol

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

3.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 8.17 h / Reflux

4.1: hydrazine / ethanol / 2 h / Reflux

4.2: 0.5 h / Heating

5.1: methanol / 20 °C

6.1: ethanol / 3 h / Reflux

7.1: 2,2,4,4-tetramethylcyclobutane-1,3-dithione / chloroform / 0 - 20 °C

With lithium aluminium tetrahydride; 2,2,4,4-tetramethylcyclobutane-1,3-dithione; triphenylphosphine; potassium hydroxide; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; chloroform; isopropyl alcohol;
DOI:10.1016/j.tetasy.2013.07.013