N,N'-bis[(5-(S)-(methoxycarbonyl)-5-[((4-trifluoromethyl)benzyloxycarbonyl)amino]pentyl)carboxamidomethyl]benzene-1,3-dicarboxamide

Base Information

Chemical Name:N,N'-bis[(5-(S)-(methoxycarbonyl)-5-[((4-trifluoromethyl)benzyloxycarbonyl)amino]pentyl)carboxamidomethyl]benzene-1,3-dicarboxamide
CAS No.:331714-10-4
Molecular Formula:C₄₄H₅₀F₆N₆O₁₂
Molecular Weight:968.904
Hs Code.:

Synonyms:N,N'-bis[(5-(S)-(methoxycarbonyl)-5-[((4-trifluoromethyl)benzyloxycarbonyl)amino]pentyl)carboxamidomethyl]benzene-1,3-dicarboxamide

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Chemical Property of N,N'-bis[(5-(S)-(methoxycarbonyl)-5-[((4-trifluoromethyl)benzyloxycarbonyl)amino]pentyl)carboxamidomethyl]benzene-1,3-dicarboxamide

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Technology Process of N,N'-bis[(5-(S)-(methoxycarbonyl)-5-[((4-trifluoromethyl)benzyloxycarbonyl)amino]pentyl)carboxamidomethyl]benzene-1,3-dicarboxamide

There total 6 articles about N,N'-bis[(5-(S)-(methoxycarbonyl)-5-[((4-trifluoromethyl)benzyloxycarbonyl)amino]pentyl)carboxamidomethyl]benzene-1,3-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99-63-8
benzene-1,3-dicarbonyl dichloride

: (S)-methyl 6-[2-(amino)acetamido]-2-[(4-trifluoromethyl)benzyloxycarbonylamino]hexanoate hydrochloride

: 331714-10-4
N,N'-bis[(5-(S)-(methoxycarbonyl)-5-[((4-trifluoromethyl)benzyloxycarbonyl)amino]pentyl)carboxamidomethyl]benzene-1,3-dicarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 1h;
DOI:10.1021/ja003579+

Reference yield:

: 349-95-1
4-(trifluoromethyl)benzylic alcohol

: 331714-10-4
N,N'-bis[(5-(S)-(methoxycarbonyl)-5-[((4-trifluoromethyl)benzyloxycarbonyl)amino]pentyl)carboxamidomethyl]benzene-1,3-dicarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / acetonitrile / 3 h / 25 °C

2: 6.4 g / acetonitrile / 3 h / 25 °C

3: HCl / dioxane; CH₂Cl₂ / 0.33 h / 25 °C

4: 2.89 g / EDCI; i-Pr₂NEt / dimethylformamide / 12 h / 25 °C

5: 99 percent / aq. HCl / dioxane; CH₂Cl₂ / 1 h / 25 °C

6: 1.30 g / i-Pr₂NEt / dimethylformamide / 1 h / 25 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja003579+

Reference yield:

: 332378-22-0
carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester 4-trifluoromethyl-benzyl ester

: 331714-10-4
N,N'-bis[(5-(S)-(methoxycarbonyl)-5-[((4-trifluoromethyl)benzyloxycarbonyl)amino]pentyl)carboxamidomethyl]benzene-1,3-dicarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 6.4 g / acetonitrile / 3 h / 25 °C

2: HCl / dioxane; CH₂Cl₂ / 0.33 h / 25 °C

3: 2.89 g / EDCI; i-Pr₂NEt / dimethylformamide / 12 h / 25 °C

4: 99 percent / aq. HCl / dioxane; CH₂Cl₂ / 1 h / 25 °C

5: 1.30 g / i-Pr₂NEt / dimethylformamide / 1 h / 25 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja003579+