(S)-methyl 6-(((tert-butyloxy)carbonyl)amino)-2-((4-trifluoromethyl)benzyloxycarbonylamino)hexanoate

Base Information

• Chemical Name: (S)-methyl 6-(((tert-butyloxy)carbonyl)amino)-2-((4-trifluoromethyl)benzyloxycarbonylamino)hexanoate
• CAS No.: 331714-05-7
• Molecular Formula: C₂₁H₂₉F₃N₂O₆
• Molecular Weight: 462.466

Synonyms:(S)-methyl 6-(((tert-butyloxy)carbonyl)amino)-2-((4-trifluoromethyl)benzyloxycarbonylamino)hexanoate

Chemical Property of (S)-methyl 6-(((tert-butyloxy)carbonyl)amino)-2-((4-trifluoromethyl)benzyloxycarbonylamino)hexanoate

Chemical Property:

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Technology Process of (S)-methyl 6-(((tert-butyloxy)carbonyl)amino)-2-((4-trifluoromethyl)benzyloxycarbonylamino)hexanoate

There total 2 articles about (S)-methyl 6-(((tert-butyloxy)carbonyl)amino)-2-((4-trifluoromethyl)benzyloxycarbonylamino)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(trifluoromethyl)benzylic alcohol (349-95-1) → (S)-methyl 6-(((tert-butyloxy)carbonyl)amino)-2-((4-trifluoromethyl)benzyloxycarbonylamino)hexanoate (331714-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / acetonitrile / 3 h / 25 °C

2: 6.4 g / acetonitrile / 3 h / 25 °C

With triethylamine; In acetonitrile;

DOI:10.1021/ja003579+

Reference yield:

N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride (2389-48-2) + carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester 4-trifluoromethyl-benzyl ester (332378-22-0) → (S)-methyl 6-(((tert-butyloxy)carbonyl)amino)-2-((4-trifluoromethyl)benzyloxycarbonylamino)hexanoate (331714-05-7)

Guidance literature:

In acetonitrile; at 25 ℃; for 3h;

DOI:10.1021/ja003579+

Reference yield:

(S)-methyl 6-(((tert-butyloxy)carbonyl)amino)-2-((4-trifluoromethyl)benzyloxycarbonylamino)hexanoate (331714-05-7) → (S)-6-Amino-2-(4-trifluoromethyl-benzyloxycarbonylamino)-hexanoic acid methyl ester (267890-00-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 25 ℃; for 1h;

DOI:10.1021/ja003579+

upstream raw materials:

N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester 4-trifluoromethyl-benzyl ester

4-(trifluoromethyl)benzylic alcohol

Downstream raw materials:

(S)-6-Amino-2-(4-trifluoromethyl-benzyloxycarbonylamino)-hexanoic acid methyl ester

N,N'-bis-[(2-[4-fluorophenyl]ethyl)carboxamidomethyl]-N,N'-bis-[N-(5-(S)-(methoxycarbonyl)-5-[((4-trifluoromethyl)benzyloxycarbonyl)amino]pentyl)carboxamidomethyl]benzene-1,3-dicarboxamide

(S)-methyl 6-[2-(benzoylamino)acetamido]-2-[(4-trifluoromethyl)-benzyloxycarbonylamino]hexanoate

(S)-methyl 6-[2-(((tert-butyloxy)carbonyl)amino)acetamido]-2-[(4-trifluoromethyl)benzyloxycarbonylamino]hexanoate

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