(1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid

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Chemical Name:(1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid
CAS No.:949588-39-0
Molecular Formula:C₁₈H₂₂N₂O₅
Molecular Weight:346.383
Hs Code.:

Synonyms:(1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid

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Chemical Property of (1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid

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Technology Process of (1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid

There total 4 articles about (1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 868364-60-7
(1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid tert-butyl ester

: 949588-39-0
(1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jo0510843

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 949588-39-0
(1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / toluene / 3.5 h / Heating

2: CF₃CO₂H; Et₃SiH / CH₂Cl₂ / 2 h / 20 °C

3: 41 percent / toluene / 6 h / Heating

4: 70 percent / CF₃CO₂H; Et₃SiH / CH₂Cl₂ / 2 h / 20 °C

With triethylsilane; trifluoroacetic acid; In dichloromethane; toluene;
DOI:10.1021/jo0510843

Reference yield:

: 517913-99-4
(1S,2R)-2-(((benzyloxy)carbonyl)amino)cyclobutanecarboxylic acid

: 949588-39-0
(1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / toluene / 6 h / Heating

2: 70 percent / CF₃CO₂H; Et₃SiH / CH₂Cl₂ / 2 h / 20 °C

With triethylsilane; trifluoroacetic acid; In dichloromethane; toluene;
DOI:10.1021/jo0510843