(1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid tert-butyl ester

Base Information

Chemical Name:(1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid tert-butyl ester
CAS No.:868364-60-7
Molecular Formula:C₂₂H₃₀N₂O₅
Molecular Weight:402.491
Hs Code.:

Synonyms:(1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid tert-butyl ester

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Chemical Property of (1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid tert-butyl ester

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Technology Process of (1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid tert-butyl ester

There total 5 articles about (1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 517913-94-9
tert-butyl (1S,2R)-2-azidocarbonylcyclobutane-1-carboxylate

: 517913-99-4
(1S,2R)-2-(((benzyloxy)carbonyl)amino)cyclobutanecarboxylic acid

: 868364-60-7
(1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid tert-butyl ester

Guidance literature:: In toluene; for 6h; Heating;
DOI:10.1021/jo0510843

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 868364-60-7
(1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / toluene / 3.5 h / Heating

2: CF₃CO₂H; Et₃SiH / CH₂Cl₂ / 2 h / 20 °C

3: 41 percent / toluene / 6 h / Heating

With triethylsilane; trifluoroacetic acid; In dichloromethane; toluene;
DOI:10.1021/jo0510843

Reference yield:

: 517913-92-7
tert-butyl (1S,2R)-2-methoxycarbonylcyclobutane-1-carboxylate

: 868364-60-7
(1S,2R)-2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclobutanecarbonyl)-amino]-cyclobutanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / NaOH / H₂O; tetrahydrofuran / 1 h / 0 °C

2.1: ethyl chloroformate; triethylamine / acetone / 3 h / 0 °C

2.2: NaN₃ / acetone; H₂O / 1.5 h / 20 °C

3.1: 41 percent / toluene / 6 h / Heating

With sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; water; acetone; toluene;
DOI:10.1021/jo0510843