3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]propanoic acid

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Chemical Name:3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]propanoic acid
CAS No.:1314881-75-8
Molecular Formula:C₂₂H₁₅N₅O₂
Molecular Weight:381.393
Hs Code.:

Synonyms:3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]propanoic acid

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Chemical Property of 3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]propanoic acid

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Technology Process of 3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]propanoic acid

There total 3 articles about 3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1314881-74-7
ethyl 3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]propanoate

: 1314881-75-8
3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]propanoic acid

Guidance literature:: ethyl 3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]propanoate; With ethanol; sodium hydroxide; In water; for 1h; Reflux;

With hydrogenchloride; In water; pH=1;
DOI:10.1016/j.bmc.2011.05.013

Reference yield:

: 1314881-73-6
ethyl 3-(4-(2,2-dicyanovinyl)phenyl)propanoate

: 1314881-75-8
3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: piperidine / ethanol / 3 h / Reflux

2.1: ethanol; sodium hydroxide / water / 1 h / Reflux

2.2: pH 1

With piperidine; ethanol; sodium hydroxide; In ethanol; water;
DOI:10.1016/j.bmc.2011.05.013

Reference yield:

: 445483-72-7
3-(4-formyl-phenyl)-propionic acid ethyl ester

: 1314881-75-8
3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3-amino propanoic acid / ethanol / 20 °C

2.1: piperidine / ethanol / 3 h / Reflux

3.1: ethanol; sodium hydroxide / water / 1 h / Reflux

3.2: pH 1

With piperidine; ethanol; sodium hydroxide; 3-amino propanoic acid; In ethanol; water; 1.1: Knoevenagel condensation;
DOI:10.1016/j.bmc.2011.05.013