3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]-N,N-dimethylpropanamide

Base Information

Chemical Name:3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]-N,N-dimethylpropanamide
CAS No.:1314881-44-1
Molecular Formula:C₂₄H₂₀N₆O
Molecular Weight:408.462
Hs Code.:

Synonyms:3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]-N,N-dimethylpropanamide

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Chemical Property of 3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]-N,N-dimethylpropanamide

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Technology Process of 3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]-N,N-dimethylpropanamide

There total 4 articles about 3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]-N,N-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1314881-75-8
3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]propanoic acid

: 124-40-3
dimethyl amine

: 1314881-44-1
3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]-N,N-dimethylpropanamide

Guidance literature:: 3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]propanoic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

dimethyl amine; In methanol; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmc.2011.05.013

Reference yield:

: 1314881-73-6
ethyl 3-(4-(2,2-dicyanovinyl)phenyl)propanoate

: 1314881-44-1
3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]-N,N-dimethylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: piperidine / ethanol / 3 h / Reflux

2.1: ethanol; sodium hydroxide / water / 1 h / Reflux

2.2: pH 1

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3.2: 20 °C

With piperidine; ethanol; 1,1'-carbonyldiimidazole; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.013

Reference yield:

: 1314881-74-7
ethyl 3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]propanoate

: 1314881-44-1
3-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenyl]-N,N-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol; sodium hydroxide / water / 1 h / Reflux

1.2: pH 1

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2.2: 20 °C

With ethanol; 1,1'-carbonyldiimidazole; sodium hydroxide; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.013