(4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid

Base Information

• Chemical Name: (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid
• CAS No.: 459431-02-8
• Molecular Formula: C₂₃H₂₁FO₆S
• Molecular Weight: 444.481
• Mol file: 459431-02-8.mol

Synonyms:(4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid

Chemical Property of (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid

There total 15 articles about (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate (459431-01-7) → (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid (459431-02-8)

Guidance literature:

With sodium hydroxide; In ethanol; water;

Reference yield:

[4-(benzyloxy)-3-bromophenyl]methanol (459430-90-1) → (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid (459431-02-8)

Guidance literature:

Multi-step reaction with 11 steps

1: water; N,N-dimethyl-formamide

2: ammonium chloride; tert.-butyl lithium / tetrahydrofuran; hexane

3: dichloromethane; ethyl acetate

4: tetra-n-butylammoniumfluoride trihydrate / tetrahydrofuran; ethyl acetate

5: dichloromethane

6: n-butyllithium; ammonium chloride / tetrahydrofuran; hexane

7: triethylsilane; ammonium chloride / tetrahydrofuran

8: tetrabutyl ammonium fluoride / 1,1-dichloroethane; ethyl acetate

9: ammonium chloride; potassium carbonate / N-methyl-acetamide

10: palladium on activated carbon / ethanol

11: sodium hydroxide / ethanol; water

With triethylsilane; sodium hydroxide; n-butyllithium; ammonium chloride; tetrabutyl ammonium fluoride; tert.-butyl lithium; potassium carbonate; tetra-n-butylammoniumfluoride trihydrate; palladium on activated carbon; In tetrahydrofuran; N-methyl-acetamide; 1,1-dichloroethane; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

({4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}oxy)(tert-butyl)dimethylsilane (459430-93-4) → (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid (459431-02-8)

Guidance literature:

Multi-step reaction with 8 steps

1: tetra-n-butylammoniumfluoride trihydrate / tetrahydrofuran; ethyl acetate

2: dichloromethane

3: n-butyllithium; ammonium chloride / tetrahydrofuran; hexane

4: triethylsilane; ammonium chloride / tetrahydrofuran

5: tetrabutyl ammonium fluoride / 1,1-dichloroethane; ethyl acetate

6: ammonium chloride; potassium carbonate / N-methyl-acetamide

7: palladium on activated carbon / ethanol

8: sodium hydroxide / ethanol; water

With triethylsilane; sodium hydroxide; n-butyllithium; ammonium chloride; tetrabutyl ammonium fluoride; potassium carbonate; tetra-n-butylammoniumfluoride trihydrate; palladium on activated carbon; In tetrahydrofuran; N-methyl-acetamide; 1,1-dichloroethane; ethanol; hexane; dichloromethane; water; ethyl acetate;

upstream raw materials:

ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate

[4-(benzyloxy)-3-bromophenyl]methanol

{[4-(benzyloxy)-3-bromobenzyl]oxy}(tert-butyl)dimethylsilane

4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzaldehyde

Refernces