ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate

Base Information

• Chemical Name: ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate
• CAS No.: 459431-01-7
• Molecular Formula: C₂₅H₂₅FO₆S
• Molecular Weight: 472.534
• Mol file: 459431-01-7.mol

Synonyms:ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate

Chemical Property of ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate

There total 14 articles about ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (4-{4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}-3,5-dimethylphenoxy)acetate (459430-99-0) → ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate (459431-01-7)

Guidance literature:

palladium on activated carbon; In ethanol;

Reference yield:

[4-(benzyloxy)-3-bromophenyl]methanol (459430-90-1) → ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate (459431-01-7)

Guidance literature:

Multi-step reaction with 10 steps

1: water; N,N-dimethyl-formamide

2: ammonium chloride; tert.-butyl lithium / tetrahydrofuran; hexane

3: dichloromethane; ethyl acetate

4: tetra-n-butylammoniumfluoride trihydrate / tetrahydrofuran; ethyl acetate

5: dichloromethane

6: n-butyllithium; ammonium chloride / tetrahydrofuran; hexane

7: triethylsilane; ammonium chloride / tetrahydrofuran

8: tetrabutyl ammonium fluoride / 1,1-dichloroethane; ethyl acetate

9: ammonium chloride; potassium carbonate / N-methyl-acetamide

10: palladium on activated carbon / ethanol

With triethylsilane; n-butyllithium; ammonium chloride; tetrabutyl ammonium fluoride; tert.-butyl lithium; potassium carbonate; tetra-n-butylammoniumfluoride trihydrate; palladium on activated carbon; In tetrahydrofuran; N-methyl-acetamide; 1,1-dichloroethane; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

({4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}oxy)(tert-butyl)dimethylsilane (459430-93-4) → ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate (459431-01-7)

Guidance literature:

Multi-step reaction with 7 steps

1: tetra-n-butylammoniumfluoride trihydrate / tetrahydrofuran; ethyl acetate

2: dichloromethane

3: n-butyllithium; ammonium chloride / tetrahydrofuran; hexane

4: triethylsilane; ammonium chloride / tetrahydrofuran

5: tetrabutyl ammonium fluoride / 1,1-dichloroethane; ethyl acetate

6: ammonium chloride; potassium carbonate / N-methyl-acetamide

7: palladium on activated carbon / ethanol

With triethylsilane; n-butyllithium; ammonium chloride; tetrabutyl ammonium fluoride; potassium carbonate; tetra-n-butylammoniumfluoride trihydrate; palladium on activated carbon; In tetrahydrofuran; N-methyl-acetamide; 1,1-dichloroethane; ethanol; hexane; dichloromethane; ethyl acetate;

upstream raw materials:

ethyl (4-{4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}-3,5-dimethylphenoxy)acetate

[4-(benzyloxy)-3-bromophenyl]methanol

{[4-(benzyloxy)-3-bromobenzyl]oxy}(tert-butyl)dimethylsilane

4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzaldehyde

Downstream raw materials:

(4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid

Refernces