ethyl 2-ethoxycarbonyl-6-phenylmethyl-2-prop-2-enyl-6-heptenoate

Base Information

• Chemical Name: ethyl 2-ethoxycarbonyl-6-phenylmethyl-2-prop-2-enyl-6-heptenoate
• CAS No.: 1225287-66-0
• Molecular Formula: C₂₂H₃₀O₄
• Molecular Weight: 358.478
• Mol file: 1225287-66-0.mol

Synonyms:ethyl 2-ethoxycarbonyl-6-phenylmethyl-2-prop-2-enyl-6-heptenoate

Chemical Property of ethyl 2-ethoxycarbonyl-6-phenylmethyl-2-prop-2-enyl-6-heptenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-ethoxycarbonyl-6-phenylmethyl-2-prop-2-enyl-6-heptenoate

There total 1 articles about ethyl 2-ethoxycarbonyl-6-phenylmethyl-2-prop-2-enyl-6-heptenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

allyl bromide (106-95-6) + phenylmagnesium bromide (100-58-3) + diethyl 3-methylenecyclohexane-1,1-dicarboxylate (177895-64-6) → ethyl 2-ethoxycarbonyl-6-phenylmethyl-2-prop-2-enyl-6-heptenoate (1225287-66-0)

Guidance literature:

phenylmagnesium bromide; With zinc dibromide; In tetrahydrofuran;

diethyl 3-methylenecyclohexane-1,1-dicarboxylate; With dibromobis(triphenylphosphine)nickel(II); In tetrahydrofuran; toluene; at 20 - 60 ℃; Inert atmosphere;

allyl bromide; In tetrahydrofuran; toluene; at 90 ℃; for 10h;

DOI:10.1021/ol100599c

Reference yield: 89.0%

ethyl 2-ethoxycarbonyl-6-phenylmethyl-2-prop-2-enyl-6-heptenoate (1225287-66-0) → diethyl-4-phenylmethyl-cyclohept-3-ene-1,1-dicarboxylate (1225287-67-1)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 20 - 70 ℃;

DOI:10.1021/ol100599c

upstream raw materials:

allyl bromide

phenylmagnesium bromide

diethyl 3-methylenecyclohexane-1,1-dicarboxylate

Downstream raw materials:

diethyl-4-phenylmethyl-cyclohept-3-ene-1,1-dicarboxylate