5-[2-(4-hydroxyphenyl)ethyl]-2-(4-methylbenzyl)-4-propyl-2,4-dihydro-[1,2,4]triazol-3-one

Base Information

Chemical Name:5-[2-(4-hydroxyphenyl)ethyl]-2-(4-methylbenzyl)-4-propyl-2,4-dihydro-[1,2,4]triazol-3-one
CAS No.:425674-59-5
Molecular Formula:C₂₁H₂₅N₃O₂
Molecular Weight:351.448
Hs Code.:

Synonyms:5-[2-(4-hydroxyphenyl)ethyl]-2-(4-methylbenzyl)-4-propyl-2,4-dihydro-[1,2,4]triazol-3-one

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Chemical Property of 5-[2-(4-hydroxyphenyl)ethyl]-2-(4-methylbenzyl)-4-propyl-2,4-dihydro-[1,2,4]triazol-3-one

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Technology Process of 5-[2-(4-hydroxyphenyl)ethyl]-2-(4-methylbenzyl)-4-propyl-2,4-dihydro-[1,2,4]triazol-3-one

There total 6 articles about 5-[2-(4-hydroxyphenyl)ethyl]-2-(4-methylbenzyl)-4-propyl-2,4-dihydro-[1,2,4]triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 425674-58-4
5-[2-(4-methoxyphenyl)ethyl]-2-(4-methylbenzyl)-4-propyl-2,4-dihydro-[1,2,4]triazol-3-one

: 425674-59-5
5-[2-(4-hydroxyphenyl)ethyl]-2-(4-methylbenzyl)-4-propyl-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: With boron tribromide; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/jm034173l

Reference yield:

: 15823-04-8
methyl 3-(4-methoxyphenyl)propionate

: 425674-59-5
5-[2-(4-hydroxyphenyl)ethyl]-2-(4-methylbenzyl)-4-propyl-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / hydrazine hydrate / methanol / 20 °C

2: tetrahydrofuran / 20 °C

3: 75 percent / KOH / methanol / 22 h / 60 - 85 °C

4: 72 percent / K₂CO₃ / dimethylformamide / 50 °C

5: 90 percent / BBr₃ / CH₂Cl₂ / 2 h / 0 °C

With potassium hydroxide; boron tribromide; potassium carbonate; hydrazine hydrate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm034173l

Reference yield:

: 1929-29-9
3-(4-methoxyphenyl)propanoic acid

: 425674-59-5
5-[2-(4-hydroxyphenyl)ethyl]-2-(4-methylbenzyl)-4-propyl-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / H₂SO₄ / 20 °C

2: 88 percent / hydrazine hydrate / methanol / 20 °C

3: tetrahydrofuran / 20 °C

4: 75 percent / KOH / methanol / 22 h / 60 - 85 °C

5: 72 percent / K₂CO₃ / dimethylformamide / 50 °C

6: 90 percent / BBr₃ / CH₂Cl₂ / 2 h / 0 °C

With potassium hydroxide; sulfuric acid; boron tribromide; potassium carbonate; hydrazine hydrate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm034173l