[(2-amino-5-hydroxy-2-indanyl)carbonyl]glycylglycyl-L-phenylalanyl-L-leucine methyl ester

Base Information

• Chemical Name: [(2-amino-5-hydroxy-2-indanyl)carbonyl]glycylglycyl-L-phenylalanyl-L-leucine methyl ester
• CAS No.: 73309-72-5
• Molecular Formula: C₃₀H₃₉N₅O₇
• Molecular Weight: 581.669
• Mol file: 73309-72-5.mol

Synonyms:[(2-amino-5-hydroxy-2-indanyl)carbonyl]glycylglycyl-L-phenylalanyl-L-leucine methyl ester

Chemical Property of [(2-amino-5-hydroxy-2-indanyl)carbonyl]glycylglycyl-L-phenylalanyl-L-leucine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(2-amino-5-hydroxy-2-indanyl)carbonyl]glycylglycyl-L-phenylalanyl-L-leucine methyl ester

There total 4 articles about [(2-amino-5-hydroxy-2-indanyl)carbonyl]glycylglycyl-L-phenylalanyl-L-leucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

<<5-(benzyloxy)-2-<(benzyloxy)carbamido>-2-indanyl>carbonyl>glycylglycyl-L-phenylalanyl-L-leucine methyl ester (84802-83-5) → [(2-amino-5-hydroxy-2-indanyl)carbonyl]glycylglycyl-L-phenylalanyl-L-leucine methyl ester (73309-72-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 20h; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00359a024

Reference yield:

2-amino-5-hydroxy-2-indancarboxylic acid (33709-81-8) → [(2-amino-5-hydroxy-2-indanyl)carbonyl]glycylglycyl-L-phenylalanyl-L-leucine methyl ester (73309-72-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) 2N aq. NaOH, CuSO₄, 3.) aq. HCl

2: 1.) 2 N aq. NaOH / 1.) heating, 2.) RT, 60 h

3: 74 percent / Et₃N, 1-hydroxybenzotriazole, DCC / CH₂Cl₂ / 56 h / Ambient temperature

4: 13 percent / H₂ / 5percent Pd/C / ethanol / 20 h / 760 Torr / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; benzotriazol-1-ol; copper(II) sulfate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm00359a024

Reference yield:

5-(benzyloxy)-2-<(benzyloxy)carbamido>-2-indancarboxylic acid (84802-82-4) → [(2-amino-5-hydroxy-2-indanyl)carbonyl]glycylglycyl-L-phenylalanyl-L-leucine methyl ester (73309-72-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / Et₃N, 1-hydroxybenzotriazole, DCC / CH₂Cl₂ / 56 h / Ambient temperature

2: 13 percent / H₂ / 5percent Pd/C / ethanol / 20 h / 760 Torr / Ambient temperature

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm00359a024

upstream raw materials:

<<5-(benzyloxy)-2-<(benzyloxy)carbamido>-2-indanyl>carbonyl>glycylglycyl-L-phenylalanyl-L-leucine methyl ester

2-amino-5-hydroxy-2-indancarboxylic acid

5-(benzyloxy)-2-<(benzyloxy)carbamido>-2-indancarboxylic acid

2-amino-5-(benzyloxy)-2-indancarboxylic acid hydrochloride