2-amino-5-(benzyloxy)-2-indancarboxylic acid hydrochloride

Base Information

• Chemical Name: 2-amino-5-(benzyloxy)-2-indancarboxylic acid hydrochloride
• CAS No.: 84802-81-3
• Molecular Formula: C₁₇H₁₇NO₃*ClH
• Molecular Weight: 319.788
• Mol file: 84802-81-3.mol

Synonyms:2-amino-5-(benzyloxy)-2-indancarboxylic acid hydrochloride

Chemical Property of 2-amino-5-(benzyloxy)-2-indancarboxylic acid hydrochloride

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of 2-amino-5-(benzyloxy)-2-indancarboxylic acid hydrochloride

There total 1 articles about 2-amino-5-(benzyloxy)-2-indancarboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-5-hydroxy-2-indancarboxylic acid (33709-81-8) + benzyl bromide (100-39-0) → 2-amino-5-(benzyloxy)-2-indancarboxylic acid hydrochloride (84802-81-3)

Guidance literature:

With hydrogenchloride; sodium hydroxide; copper(II) sulfate; Yield given. Multistep reaction;

DOI:10.1021/jm00359a024

Reference yield:

2-amino-5-(benzyloxy)-2-indancarboxylic acid hydrochloride (84802-81-3) → [(2-amino-5-hydroxy-2-indanyl)carbonyl]glycylglycyl-L-phenylalanyl-L-leucine methyl ester (73309-72-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 2 N aq. NaOH / 1.) heating, 2.) RT, 60 h

2: 74 percent / Et₃N, 1-hydroxybenzotriazole, DCC / CH₂Cl₂ / 56 h / Ambient temperature

3: 13 percent / H₂ / 5percent Pd/C / ethanol / 20 h / 760 Torr / Ambient temperature

With sodium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm00359a024

Reference yield:

2-amino-5-(benzyloxy)-2-indancarboxylic acid hydrochloride (84802-81-3) → <<5-(benzyloxy)-2-<(benzyloxy)carbamido>-2-indanyl>carbonyl>glycylglycyl-L-phenylalanyl-L-leucine methyl ester (84802-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 2 N aq. NaOH / 1.) heating, 2.) RT, 60 h

2: 74 percent / Et₃N, 1-hydroxybenzotriazole, DCC / CH₂Cl₂ / 56 h / Ambient temperature

With sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/jm00359a024

upstream raw materials:

2-amino-5-hydroxy-2-indancarboxylic acid

benzyl bromide

Downstream raw materials:

[(2-amino-5-hydroxy-2-indanyl)carbonyl]glycylglycyl-L-phenylalanyl-L-leucine methyl ester

<<5-(benzyloxy)-2-<(benzyloxy)carbamido>-2-indanyl>carbonyl>glycylglycyl-L-phenylalanyl-L-leucine methyl ester