6-(5-Acetyl-2-trifluoromethoxy-phenyl)-4-ethyl-2,2,7-trimethyl-4H-benzo[1,4]oxazin-3-one

Base Information

Chemical Name:6-(5-Acetyl-2-trifluoromethoxy-phenyl)-4-ethyl-2,2,7-trimethyl-4H-benzo[1,4]oxazin-3-one
CAS No.:932384-56-0
Molecular Formula:C₂₂H₂₂F₃NO₄
Molecular Weight:421.416
Hs Code.:

Synonyms:6-(5-Acetyl-2-trifluoromethoxy-phenyl)-4-ethyl-2,2,7-trimethyl-4H-benzo[1,4]oxazin-3-one

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Chemical Property of 6-(5-Acetyl-2-trifluoromethoxy-phenyl)-4-ethyl-2,2,7-trimethyl-4H-benzo[1,4]oxazin-3-one

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Technology Process of 6-(5-Acetyl-2-trifluoromethoxy-phenyl)-4-ethyl-2,2,7-trimethyl-4H-benzo[1,4]oxazin-3-one

There total 7 articles about 6-(5-Acetyl-2-trifluoromethoxy-phenyl)-4-ethyl-2,2,7-trimethyl-4H-benzo[1,4]oxazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 932384-38-8
3-(4-Ethyl-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-4-trifluoromethoxy-benzaldehyde

: 75-16-1
methylmagnesium bromide

: 932384-56-0
6-(5-Acetyl-2-trifluoromethoxy-phenyl)-4-ethyl-2,2,7-trimethyl-4H-benzo[1,4]oxazin-3-one

Guidance literature:: 3-(4-Ethyl-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-4-trifluoromethoxy-benzaldehyde; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃;

With ammonium chloride; In tetrahydrofuran; diethyl ether; water;

With Dess-Martin periodane; In dichloromethane; at 20 ℃;

Reference yield:

: C₂₂H₂₄NO₄F₃

: 932384-56-0
6-(5-Acetyl-2-trifluoromethoxy-phenyl)-4-ethyl-2,2,7-trimethyl-4H-benzo[1,4]oxazin-3-one

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2007.01.047

Reference yield:

: 459810-97-0
3-formyl-6-trifluoromethoxy-1-phenyl boronic acid

: 932384-56-0
6-(5-Acetyl-2-trifluoromethoxy-phenyl)-4-ethyl-2,2,7-trimethyl-4H-benzo[1,4]oxazin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: aq. K₂CO₃ / Pd(PPh₃)4 / toluene; ethanol / Heating

2: tetrahydrofuran; diethyl ether / -78 - 20 °C

3: Dess-Martin reagent / CH₂Cl₂ / 20 °C

With potassium carbonate; Dess-Martin periodane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; toluene; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.01.047