4-(((3-chlorophenyl)((4-methylthiazol-5-yl)methyl)amino)methyl)-8-fluoroquinolin-2(1H)-one

Base Information

Chemical Name:4-(((3-chlorophenyl)((4-methylthiazol-5-yl)methyl)amino)methyl)-8-fluoroquinolin-2(1H)-one
CAS No.:953065-72-0
Molecular Formula:C₂₁H₁₇ClFN₃OS
Molecular Weight:413.903
Hs Code.:

Synonyms:4-(((3-chlorophenyl)((4-methylthiazol-5-yl)methyl)amino)methyl)-8-fluoroquinolin-2(1H)-one

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Chemical Property of 4-(((3-chlorophenyl)((4-methylthiazol-5-yl)methyl)amino)methyl)-8-fluoroquinolin-2(1H)-one

Chemical Property:

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Technology Process of 4-(((3-chlorophenyl)((4-methylthiazol-5-yl)methyl)amino)methyl)-8-fluoroquinolin-2(1H)-one

There total 3 articles about 4-(((3-chlorophenyl)((4-methylthiazol-5-yl)methyl)amino)methyl)-8-fluoroquinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 953070-62-7
3-chloro-N-((4-methylthiazol-5-yl)methyl)aniline

: 176912-29-1
4-(bromomethyl)-8-fluoroquinolin-2(1H)-one

: 953065-72-0
4-(((3-chlorophenyl)((4-methylthiazol-5-yl)methyl)amino)methyl)-8-fluoroquinolin-2(1H)-one

Guidance literature:: With potassium iodide; In dimethyl sulfoxide; at 20 - 90 ℃; for 4h;

Reference yield:

: 20485-41-0
4-methylthiazole-5-carboxylic acid

: 953065-72-0
4-(((3-chlorophenyl)((4-methylthiazol-5-yl)methyl)amino)methyl)-8-fluoroquinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2: triethylamine / dmap / 1-methyl-pyrrolidin-2-one; dichloromethane / 2 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Heating / reflux

4: potassium iodide / dimethyl sulfoxide / 4 h / 20 - 90 °C

With lithium aluminium tetrahydride; oxalyl dichloride; triethylamine; potassium iodide; dmap; N,N-dimethyl-formamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 953070-60-5
N-(3-chlorophenyl)-4-methylthiazole-5-carboxamide

: 953065-72-0
4-(((3-chlorophenyl)((4-methylthiazol-5-yl)methyl)amino)methyl)-8-fluoroquinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Heating / reflux

2: potassium iodide / dimethyl sulfoxide / 4 h / 20 - 90 °C

With lithium aluminium tetrahydride; potassium iodide; In tetrahydrofuran; dimethyl sulfoxide;