4-Methylthiazole-5-carboxylic acid

Base Information

Chemical Name:4-Methylthiazole-5-carboxylic acid
CAS No.:20485-41-0
Molecular Formula:C5H5NO2S
Molecular Weight:143.166
Hs Code.:29341000
European Community (EC) Number:606-565-5
DSSTox Substance ID:DTXSID00174452
Nikkaji Number:J59.603E
Wikidata:Q72491186
ChEMBL ID:CHEMBL1402698
Mol file:20485-41-0.mol

Synonyms:4-methylthiazole-5-carboxylic acid

Suppliers and Price of 4-Methylthiazole-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Methylthiazole-5-carboxylic Acid
1g
$ 65.00

TCI Chemical
4-Methylthiazole-5-carboxylic Acid >97.0%(GC)(T)
5g
$ 50.00

SynQuest Laboratories
4-Methyl-1,3-thiazole-5-carboxylic acid 95%
100 g
$ 237.00

SynQuest Laboratories
4-Methyl-1,3-thiazole-5-carboxylic acid 95%
10 g
$ 36.00

SynQuest Laboratories
4-Methyl-1,3-thiazole-5-carboxylic acid 95%
1 g
$ 16.00

Sigma-Aldrich
4-Methylthiazole-5-carboxylic acid 97%
1g
$ 57.30

Sigma-Aldrich
4-Methylthiazole-5-carboxylic acid 97%
10g
$ 361.00

Medical Isotopes, Inc.
4-Methylthiazole-5-carboxylic Acid
10 g
$ 825.00

Medical Isotopes, Inc.
4-Methylthiazole-5-carboxylic Acid
1 g
$ 610.00

Matrix Scientific
4-Methyl-1,3-thiazole-5-carboxylic acid 98%
100g
$ 275.00

Total 72 raw suppliers

Chemical Property of 4-Methylthiazole-5-carboxylic acid

Chemical Property:

Appearance/Colour:white to light yellow crystal powder
Vapor Pressure:0.003mmHg at 25°C
Melting Point:287 °C (dec.)(lit.)
Refractive Index:1.611
Boiling Point:303.6 °C at 760 mmHg
PKA:1.16±0.31(Predicted)
Flash Point:137.413 °C
PSA：78.43000
Density:1.418 g/cm³
LogP:1.14970
Storage Temp.:Room temperature.
Solubility.:DMSO
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:143.00409958
Heavy Atom Count:9
Complexity:128

Purity/Quality:

99% ^*data from raw suppliers

4-Methylthiazole-5-carboxylic Acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 43-36/37/38
Safety Statements: 37/39-26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(SC=N1)C(=O)O
Uses 4-Methylthiazole-5-carboxylic acid is used as a reagent to synthesize thiazolylimidazolidinone compounds that act as Stearoyl-CoA desaturase-1 (SCD1) inhibitors. These SCD1 inhibitors are used in the treatment of metabolic diseases. 4-Methylthiazole-5-carboxylic acid is also used as a reagent to synthesize 4-Methyl-5-formylthiazole, an important intermediate in the synthesis of Cefditoren pivoxil (C242700).

Technology Process of 4-Methylthiazole-5-carboxylic acid

There total 6 articles about 4-Methylthiazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.8%

: 77287-34-4,77287-35-5,60100-09-6
formamide

: 609-15-4
ethyl 2-chloro-3-oxo-butyrate

: 20485-41-0
4-methylthiazole-5-carboxylic acid

Guidance literature:: formamide; With tetraphosphorus decasulfide; In 1,2-dimethoxyethane; for 2h; Inert atmosphere; Large scale;

ethyl 2-chloro-3-oxo-butyrate; In 1,2-dimethoxyethane; at 60 ℃; for 8h; Large scale;