(4R,6S)-4-Ethyl-3-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-6-methyl-cyclohex-2-enone

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Chemical Name:(4R,6S)-4-Ethyl-3-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-6-methyl-cyclohex-2-enone
CAS No.:186887-38-7
Molecular Formula:C₁₇H₂₇NO₄
Molecular Weight:309.406
Hs Code.:

Synonyms:(4R,6S)-4-Ethyl-3-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-6-methyl-cyclohex-2-enone

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Chemical Property of (4R,6S)-4-Ethyl-3-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-6-methyl-cyclohex-2-enone

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Technology Process of (4R,6S)-4-Ethyl-3-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-6-methyl-cyclohex-2-enone

There total 3 articles about (4R,6S)-4-Ethyl-3-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-6-methyl-cyclohex-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 186887-37-6
(R)-4-Ethyl-5-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-2-methyl-cyclohexa-2,5-dienone

: 186887-38-7
(4R,6S)-4-Ethyl-3-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-6-methyl-cyclohex-2-enone

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 4h;
DOI:10.1021/jo961603p

Reference yield:

: 115512-81-7
(S)-2-methoxy-1-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-5-methylbenzene

: 186887-38-7
(4R,6S)-4-Ethyl-3-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-6-methyl-cyclohex-2-enone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) t-BuOH, K, NH₃ / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 1.5 h; -78 deg C -> 25 deg C

2: 92 percent / PDC, Celite, t-BuOOH / benzene

3: 90 percent / H₂ / Pd/C / ethyl acetate / 4 h

With tert.-butylhydroperoxide; dipyridinium dichromate; Celite; ammonia; hydrogen; tert-butyl alcohol; palladium on activated charcoal; In ethyl acetate; benzene;
DOI:10.1021/jo961603p

Reference yield:

: 186887-36-5
(2'S,6R)-6-ethyl-1-methoxy-6-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-4-methyl-1,4-cyclohexadiene

: 186887-38-7
(4R,6S)-4-Ethyl-3-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-6-methyl-cyclohex-2-enone

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / PDC, Celite, t-BuOOH / benzene

2: 90 percent / H₂ / Pd/C / ethyl acetate / 4 h

With tert.-butylhydroperoxide; dipyridinium dichromate; Celite; hydrogen; palladium on activated charcoal; In ethyl acetate; benzene;
DOI:10.1021/jo961603p