(2S,4R,5S)-4-Ethyl-5-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-2-methyl-cyclohexanone

Base Information

Chemical Name:(2S,4R,5S)-4-Ethyl-5-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-2-methyl-cyclohexanone
CAS No.:186887-39-8
Molecular Formula:C₁₇H₂₉NO₄
Molecular Weight:311.422
Hs Code.:

Synonyms:(2S,4R,5S)-4-Ethyl-5-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-2-methyl-cyclohexanone

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Chemical Property of (2S,4R,5S)-4-Ethyl-5-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-2-methyl-cyclohexanone

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Technology Process of (2S,4R,5S)-4-Ethyl-5-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-2-methyl-cyclohexanone

There total 4 articles about (2S,4R,5S)-4-Ethyl-5-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-2-methyl-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 186887-38-7
(4R,6S)-4-Ethyl-3-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-6-methyl-cyclohex-2-enone

: 186887-39-8
(2S,4R,5S)-4-Ethyl-5-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-2-methyl-cyclohexanone

Guidance literature:: With ammonia; lithium; tert-butyl alcohol; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/jo961603p

Reference yield:

: 115512-81-7
(S)-2-methoxy-1-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-5-methylbenzene

: 186887-39-8
(2S,4R,5S)-4-Ethyl-5-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-2-methyl-cyclohexanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) t-BuOH, K, NH₃ / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 1.5 h; -78 deg C -> 25 deg C

2: 92 percent / PDC, Celite, t-BuOOH / benzene

3: 90 percent / H₂ / Pd/C / ethyl acetate / 4 h

4: 88 percent / NH₃, Li, t-BuOH / tetrahydrofuran / -78 °C

With tert.-butylhydroperoxide; dipyridinium dichromate; Celite; ammonia; hydrogen; lithium; tert-butyl alcohol; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1021/jo961603p

Reference yield:

: 186887-36-5
(2'S,6R)-6-ethyl-1-methoxy-6-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-4-methyl-1,4-cyclohexadiene

: 186887-39-8
(2S,4R,5S)-4-Ethyl-5-methoxy-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-2-methyl-cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / PDC, Celite, t-BuOOH / benzene

2: 90 percent / H₂ / Pd/C / ethyl acetate / 4 h

3: 88 percent / NH₃, Li, t-BuOH / tetrahydrofuran / -78 °C

With tert.-butylhydroperoxide; dipyridinium dichromate; Celite; ammonia; hydrogen; lithium; tert-butyl alcohol; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1021/jo961603p