Technology Process of 4-(1-(5-chloro-2-(3-(3-fluorobenzoyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoic acid
There total 11 articles about 4-(1-(5-chloro-2-(3-(3-fluorobenzoyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 4-(1-(5-chloro-2-(3-(3-fluorobenzoyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate;
With
lithium hydroxide monohydrate; water;
In
1,4-dioxane;
at 70 ℃;
for 0.333333h;
Microwave irradiation;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 5 h / Molecular sieve; Reflux
2.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide; methanol / 48 h / 80 °C / 30003 Torr
3.1: hydrogenchloride / ethyl acetate / 20 °C
4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate / N,N-dimethyl-formamide / 1 h / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
5.2: 75 - 80 °C
6.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 0.33 h / 70 °C / Microwave irradiation
With
hydrogenchloride; lithium hydroxide monohydrate; diphenyl phosphoryl azide; 1-hydroxy-1H-benzotriazol hydrate; 1,3-bis-(diphenylphosphino)propane; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
palladium diacetate;
In
1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide; methanol / 48 h / 80 °C / 30003 Torr
2.1: hydrogenchloride / ethyl acetate / 20 °C
3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate / N,N-dimethyl-formamide / 1 h / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
4.2: 75 - 80 °C
5.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 0.33 h / 70 °C / Microwave irradiation
With
hydrogenchloride; lithium hydroxide monohydrate; 1-hydroxy-1H-benzotriazol hydrate; 1,3-bis-(diphenylphosphino)propane; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
palladium diacetate;
In
1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
