(2S,3R)-3-Benzyloxy-2-[(2S,3R)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-hydroxy-butyrylamino]-butyric acid (R)-1-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetradecyl ester

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Chemical Name:(2S,3R)-3-Benzyloxy-2-[(2S,3R)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-hydroxy-butyrylamino]-butyric acid (R)-1-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetradecyl ester
CAS No.:867156-37-4
Molecular Formula:C₄₈H₈₃N₃O₁₀
Molecular Weight:862.201
Hs Code.:

(2S,3R)-3-Benzyloxy-2-[(2S,3R)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-hydroxy-butyrylamino]-butyric acid (R)-1-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetradecyl ester

Synonyms:(2S,3R)-3-Benzyloxy-2-[(2S,3R)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-hydroxy-butyrylamino]-butyric acid (R)-1-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetradecyl ester

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Chemical Property of (2S,3R)-3-Benzyloxy-2-[(2S,3R)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-hydroxy-butyrylamino]-butyric acid (R)-1-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetradecyl ester

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Technology Process of (2S,3R)-3-Benzyloxy-2-[(2S,3R)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-hydroxy-butyrylamino]-butyric acid (R)-1-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetradecyl ester

There total 4 articles about (2S,3R)-3-Benzyloxy-2-[(2S,3R)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-hydroxy-butyrylamino]-butyric acid (R)-1-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetradecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 867156-31-8
(2S,3R)-3-Benzyloxy-2-benzyloxycarbonylamino-butyric acid (R)-1-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetradecyl ester

: 867156-37-4
(2S,3R)-3-Benzyloxy-2-[(2S,3R)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-hydroxy-butyrylamino]-butyric acid (R)-1-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetradecyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C-ethylenediamine complex / methanol / 0.5 h / 25 °C

2: 79 mg / HOBt; EDCI / dimethylformamide / 0.5 h / 25 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; ethylenediamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo050628y

Reference yield:

: 69863-36-1
N-benzyloxycarbonyl-O-benzyl-L-threonine

: 867156-37-4
(2S,3R)-3-Benzyloxy-2-[(2S,3R)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-hydroxy-butyrylamino]-butyric acid (R)-1-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetradecyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / DMAP; CSA; DCC / CH₂Cl₂ / 0.75 h / 0 - 25 °C

2: H₂ / Pd/C-ethylenediamine complex / methanol / 0.5 h / 25 °C

3: 79 mg / HOBt; EDCI / dimethylformamide / 0.5 h / 25 °C

With dmap; camphor-10-sulfonic acid; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; palladium on activated charcoal; ethylenediamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo050628y

Reference yield:

: 467224-46-0
(2S,3R)-2-((4S,5S)-2,2,5-Trimethyl-[1,3]dioxan-4-yl)-hexadecan-3-ol

: 867156-37-4
(2S,3R)-3-Benzyloxy-2-[(2S,3R)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-hydroxy-butyrylamino]-butyric acid (R)-1-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetradecyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / DMAP; CSA; DCC / CH₂Cl₂ / 0.75 h / 0 - 25 °C

2: H₂ / Pd/C-ethylenediamine complex / methanol / 0.5 h / 25 °C

3: 79 mg / HOBt; EDCI / dimethylformamide / 0.5 h / 25 °C

With dmap; camphor-10-sulfonic acid; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; palladium on activated charcoal; ethylenediamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo050628y