ethyl 2-benzyl-2-nitrobut-3-ynoate

Base Information

• Chemical Name: ethyl 2-benzyl-2-nitrobut-3-ynoate
• CAS No.: 1252671-72-9
• Molecular Formula: C₁₃H₁₃NO₄
• Molecular Weight: 247.251
• Mol file: 1252671-72-9.mol

Synonyms:ethyl 2-benzyl-2-nitrobut-3-ynoate

Chemical Property of ethyl 2-benzyl-2-nitrobut-3-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-benzyl-2-nitrobut-3-ynoate

There total 2 articles about ethyl 2-benzyl-2-nitrobut-3-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethyl 3-phenyl-2-nitropropionate (16782-23-3) + 1-[(trimethylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one → ethyl 2-benzyl-2-nitrobut-3-ynoate (1252671-72-9)

Guidance literature:

ethyl 3-phenyl-2-nitropropionate; 1-[(trimethylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one; In tetrahydrofuran; at -78 ℃; for 0.0833333h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

DOI:10.1002/chem.201001539

Reference yield: 46.0%

ethyl 3-phenyl-2-nitropropionate (16782-23-3) + ethynyl(phenyl)(tetrafluoroborato)-λ3-iodane → ethyl 2-benzyl-2-nitrobut-3-ynoate (1252671-72-9)

Guidance literature:

ethyl 3-phenyl-2-nitropropionate; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

ethynyl(phenyl)(tetrafluoroborato)-λ³-iodane; In tetrahydrofuran; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1002/chem.201001539

Reference yield: 94.0%

ethyl 2-benzyl-2-nitrobut-3-ynoate (1252671-72-9) → ethyl 2-benzyl-2-(hydroxyamino)but-3-ynoate (1252671-77-4)

Guidance literature:

With ammonium chloride; zinc; In tetrahydrofuran; ethanol; water; at 0 ℃; for 0.75h; Inert atmosphere;

DOI:10.1002/chem.201001539

upstream raw materials:

ethyl 3-phenyl-2-nitropropionate

Downstream raw materials:

ethyl 2-benzyl-2-(hydroxyamino)but-3-ynoate

ethyl 2-amino-2-benzylbut-3-enoate

ethyl 2-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-nitro-3-phenylpropanoate

Refernces