t-butyl 3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propanoate

Base Information

Chemical Name:t-butyl 3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propanoate
CAS No.:1445985-16-9
Molecular Formula:C₂₉H₃₆ClN₃O₃
Molecular Weight:510.076
Hs Code.:

Synonyms:t-butyl 3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propanoate

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Chemical Property of t-butyl 3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propanoate

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Technology Process of t-butyl 3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propanoate

There total 12 articles about t-butyl 3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1445985-15-8
tert-butyl 3-(3-(bromomethyl)-4-chlorophenyl)propanoate

: 1445985-96-5
(1-aminocyclopropyl)(4-cyclopropyl-3,4-dihydroquinoxalin-1-(2H)-yl)methanone hydrochloride

: 1445985-16-9
t-butyl 3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; potassium iodide; In acetonitrile; at 50 ℃;

Reference yield:

: 1445984-88-2
t-butyl (1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)carbamate

: 1445985-16-9
t-butyl 3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane

2: N-ethyl-N,N-diisopropylamine; potassium iodide / acetonitrile / 50 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; potassium iodide; In 1,4-dioxane; acetonitrile;

Reference yield:

: 1224640-11-2
1-cyclopropyl-4-hydroxy-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445985-16-9
t-butyl 3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine / N,N-dimethyl-formamide / 2 h / 135 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 4 h / 50 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 - 50 °C

4: hydrogenchloride / 1,4-dioxane

5: N-ethyl-N,N-diisopropylamine; potassium iodide / acetonitrile / 50 °C

With hydrogenchloride; borane-THF; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; potassium iodide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;