N-(3-{2-[(thiophen-3-ylmethyl)-amino]-pyrimidin-4-yl}-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-cyclohexane-1,4-diamine hydrochloride

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Chemical Name:N-(3-{2-[(thiophen-3-ylmethyl)-amino]-pyrimidin-4-yl}-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-cyclohexane-1,4-diamine hydrochloride
CAS No.:1386398-45-3
Molecular Formula:C₂₀H₂₃N₉S*ClH
Molecular Weight:457.99
Hs Code.:

Synonyms:N-(3-{2-[(thiophen-3-ylmethyl)-amino]-pyrimidin-4-yl}-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-cyclohexane-1,4-diamine hydrochloride

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Chemical Property of N-(3-{2-[(thiophen-3-ylmethyl)-amino]-pyrimidin-4-yl}-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-cyclohexane-1,4-diamine hydrochloride

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Technology Process of N-(3-{2-[(thiophen-3-ylmethyl)-amino]-pyrimidin-4-yl}-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-cyclohexane-1,4-diamine hydrochloride

There total 7 articles about N-(3-{2-[(thiophen-3-ylmethyl)-amino]-pyrimidin-4-yl}-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-cyclohexane-1,4-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1386399-39-8
[4-(3-{2-[(thiophen-3-ylmethyl)-amino]-pyrimidin-4-yl}-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester

: 1386398-45-3
N-(3-{2-[(thiophen-3-ylmethyl)-amino]-pyrimidin-4-yl}-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-cyclohexane-1,4-diamine hydrochloride

Guidance literature:: With hydrogenchloride; methanol; at 20 ℃; for 3h;

Reference yield:

: 1074-68-6
4-formyl-2-(methylthio)pyrimidine

: 1386398-45-3
N-(3-{2-[(thiophen-3-ylmethyl)-amino]-pyrimidin-4-yl}-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-cyclohexane-1,4-diamine hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -30 °C

1.2: 1 h / -30 - 0 °C

1.3: 0 °C

2.1: manganese(IV) oxide / methanol; dichloromethane / 16 h / Reflux

3.1: hydrazine hydrate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 50 °C

4.1: triethylamine / isopropyl alcohol / 15 h / Reflux

5.1: 3-chloro-benzenecarboperoxoic acid / methanol; dichloromethane / 0.42 h / 20 °C

6.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / 1,4-dioxane / 12 h / 102 °C / Inert atmosphere; Sealed tube

7.1: hydrogenchloride; methanol / 3 h / 20 °C

With hydrogenchloride; methanol; manganese(IV) oxide; isopropylmagnesium chloride; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; isopropyl alcohol;

Reference yield:

: 1386398-83-9
6-chloro-3-(2-methylsulfanyl-pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine

: 1386398-45-3
N-(3-{2-[(thiophen-3-ylmethyl)-amino]-pyrimidin-4-yl}-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-cyclohexane-1,4-diamine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / isopropyl alcohol / 15 h / Reflux

2: 3-chloro-benzenecarboperoxoic acid / methanol; dichloromethane / 0.42 h / 20 °C

3: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / 1,4-dioxane / 12 h / 102 °C / Inert atmosphere; Sealed tube

4: hydrogenchloride; methanol / 3 h / 20 °C

With hydrogenchloride; methanol; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; In 1,4-dioxane; methanol; dichloromethane; isopropyl alcohol;