N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(2-oxopyridin-1(2H)-yl)phenyl)acetamide

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Chemical Name:N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(2-oxopyridin-1(2H)-yl)phenyl)acetamide
CAS No.:1430724-84-7
Molecular Formula:C₂₄H₂₀N₆O₂
Molecular Weight:424.462
Hs Code.:

Synonyms:N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(2-oxopyridin-1(2H)-yl)phenyl)acetamide

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Chemical Property of N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(2-oxopyridin-1(2H)-yl)phenyl)acetamide

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Technology Process of N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(2-oxopyridin-1(2H)-yl)phenyl)acetamide

There total 9 articles about N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(2-oxopyridin-1(2H)-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1430728-56-5
N-(3-(5-bromo-1H-benzo[d]imidazol-1-yl)-5-(2-oxopyridin-1(2H)-yl)phenyl)-acetamide

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1430724-84-7
N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(2-oxopyridin-1(2H)-yl)phenyl)acetamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 18242-39-2
3,5-dinitrobromobenzene

: 1430724-84-7
N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(2-oxopyridin-1(2H)-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: acetic acid; iron / acetic acid / 0.5 h / 90 °C

2: 0.5 h / 0 - 20 °C

3: potassium carbonate; copper(l) iodide; trans-1,2-Diaminocyclohexane / toluene / 16 h / 100 °C

4: water; calcium chloride; iron / ethanol / 4 h / 100 °C

5: potassium fluoride / N,N-dimethyl-formamide / 2 h / 150 °C

6: calcium chloride; iron / ethanol / 4 h / 100 °C

7: 2 h / 100 °C

8: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

With potassium fluoride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-1,2-Diaminocyclohexane; water; iron; sodium carbonate; potassium carbonate; acetic acid; calcium chloride; In 1,2-dimethoxyethane; ethanol; water; acetic acid; N,N-dimethyl-formamide; toluene;

Reference yield:

: 99-65-0
meta-dinitrobenzene

: 1430724-84-7
N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(2-oxopyridin-1(2H)-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: sulfuric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / 12.5 h / 0 - 20 °C

2: acetic acid; iron / acetic acid / 0.5 h / 90 °C

3: 0.5 h / 0 - 20 °C

4: potassium carbonate; copper(l) iodide; trans-1,2-Diaminocyclohexane / toluene / 16 h / 100 °C

5: water; calcium chloride; iron / ethanol / 4 h / 100 °C

6: potassium fluoride / N,N-dimethyl-formamide / 2 h / 150 °C

7: calcium chloride; iron / ethanol / 4 h / 100 °C

8: 2 h / 100 °C

9: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

With potassium fluoride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; trans-1,2-Diaminocyclohexane; water; iron; sodium carbonate; potassium carbonate; acetic acid; calcium chloride; In 1,2-dimethoxyethane; ethanol; water; acetic acid; N,N-dimethyl-formamide; toluene;