Methyl 3-amino-4,4,4-trifluorobutyrate hydrochloride

Base Information

Chemical Name:Methyl 3-amino-4,4,4-trifluorobutyrate hydrochloride
CAS No.:169605-23-6
Molecular Formula:C₅H₈F₃NO₂*ClH
Molecular Weight:207.58
Hs Code.:2922499990
Mol file:169605-23-6.mol

Synonyms:Butanoicacid, 3-amino-4,4,4-trifluoro-, methyl ester, hydrochloride (9CI)

Suppliers and Price of Methyl 3-amino-4,4,4-trifluorobutyrate hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Methyl 3-amino-4,4,4-trifluorobutyrate hydrochloride 95%
250mg
$ 76.00

American Custom Chemicals Corporation
METHYL 3-AMINO-4,4,4-TRIFLUOROBUTYRATE HYDROCHLORIDE 95.00%
250MG
$ 636.81

Total 7 raw suppliers

Chemical Property of Methyl 3-amino-4,4,4-trifluorobutyrate hydrochloride

Chemical Property:

Vapor Pressure:0.177mmHg at 25°C
Melting Point:96-101 °C
Boiling Point:208.5°Cat760mmHg
Flash Point:79.9°C
PSA：52.32000
Density:g/cm³
LogP:1.94140
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl 3-amino-4,4,4-trifluorobutyrate hydrochloride 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:F,Xi
Statements: 36-43
Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of Methyl 3-amino-4,4,4-trifluorobutyrate hydrochloride

There total 1 articles about Methyl 3-amino-4,4,4-trifluorobutyrate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83643-84-9,488711-09-7
methyl 4,4,4-trifluoroacetoacetate

: 169605-23-6
methyl (R,S)-3-amino-4,4,4-trifluorobutyrate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / cation exchange resin Dowex 50 H⁺ form / benzene / Heating

2: 84 percent / Et₃N / 12 h / Heating

3: 2 N aq. HCl / diethyl ether / 2 h / Ambient temperature

With hydrogenchloride; cation exchange resin Dowex 50 H⁺ form; triethylamine; In diethyl ether; benzene;
DOI:10.1016/0040-4020(96)00300-6

Reference yield: 80.0%

: 169605-23-6
(1S,2S)-2-(tert-butoxycarbonylamino)cyclohexanecarboxylic acid benzyl ester

: 488703-60-2,209128-50-7
(1S,2S)-2-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid

: C₁₇H₂₇F₃N₂O₅

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1039/c4cc02136c

Reference yield: 73.0%

: 1149677-57-5,169605-23-6
(S)-3-amino-4,4,4-trifluorobutyric acid methyl ester hydrochloride

: 23680-31-1
BOC-O-benzyl-L-serine

: 1458674-57-1
C₂₀H₂₇F₃N₂O₆

Guidance literature:: BOC-O-benzyl-L-serine; With 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In dichloromethane; at 0 - 20 ℃;

(S)-3-amino-4,4,4-trifluorobutyric acid methyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2013.08.051