rac-methyl 3-[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-4,4,4-trifluorobutanoate

Base Information

Chemical Name:rac-methyl 3-[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-4,4,4-trifluorobutanoate
CAS No.:1609082-04-3
Molecular Formula:C₂₁H₁₈F₅N₃O₄
Molecular Weight:471.384
Hs Code.:

Synonyms:rac-methyl 3-[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-4,4,4-trifluorobutanoate

Suppliers and Price of rac-methyl 3-[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-4,4,4-trifluorobutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of rac-methyl 3-[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-4,4,4-trifluorobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of rac-methyl 3-[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-4,4,4-trifluorobutanoate

There total 5 articles about rac-methyl 3-[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-4,4,4-trifluorobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1415501-19-7
8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a] pyridine-3-carboxylic acid

: 169605-23-6
methyl (R,S)-3-amino-4,4,4-trifluorobutyrate hydrochloride

: 1609082-04-3
rac-methyl 3-[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-4,4,4-trifluorobutanoate

Guidance literature:: 8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a] pyridine-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 60 ℃; for 0.333333h;

methyl (R,S)-3-amino-4,4,4-trifluorobutyrate hydrochloride; In N,N-dimethyl-formamide; at 60 ℃;

Reference yield:

: 16867-03-1
2-amino-3-hydroxypyridine

: 1609082-04-3
rac-methyl 3-[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-4,4,4-trifluorobutanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 0.25 h / 20 °C

1.2: 4 h / 20 °C

2.1: ethanol / 24 h / Molecular sieve; Reflux

3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 16 h / 20 °C

4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 60 °C

4.2: 60 °C

With water; sodium methylate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 85118-00-9
2,6-Difluorobenzyl bromide

: 1609082-04-3
rac-methyl 3-[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-4,4,4-trifluorobutanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 0.25 h / 20 °C

1.2: 4 h / 20 °C

2.1: ethanol / 24 h / Molecular sieve; Reflux

3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 16 h / 20 °C

4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 60 °C

4.2: 60 °C

With water; sodium methylate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;