Technology Process of ethyl 4-(4-(3-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)ureido)phenoxy)butanoate
There total 8 articles about ethyl 4-(4-(3-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)ureido)phenoxy)butanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-Nitrophenyl chloroformate; 2-amino-5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-thiazole;
With
triethylamine;
In
dichloromethane;
at 0 ℃;
for 2h;
4-(4-aminofenossi)butirrato di etile;
In
dichloromethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium azide / acetone / 25 °C
2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol
3.1: triethylamine / dichloromethane / 1.25 h / -10 - -5 °C
4.1: trichlorophosphate / 1 h / 105 °C
5.1: ethanol; sodium tetrahydroborate / acetone / 1 h / 20 °C
5.2: 1 h / Reflux
6.1: triethylamine / dichloromethane / 2 h / 0 °C
6.2: 20 °C
With
hydrogenchloride; sodium tetrahydroborate; sodium azide; ethanol; hydrogen; triethylamine; trichlorophosphate;
palladium 10% on activated carbon;
In
methanol; dichloromethane; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol
2.1: triethylamine / dichloromethane / 1.25 h / -10 - -5 °C
3.1: trichlorophosphate / 1 h / 105 °C
4.1: ethanol; sodium tetrahydroborate / acetone / 1 h / 20 °C
4.2: 1 h / Reflux
5.1: triethylamine / dichloromethane / 2 h / 0 °C
5.2: 20 °C
With
hydrogenchloride; sodium tetrahydroborate; ethanol; hydrogen; triethylamine; trichlorophosphate;
palladium 10% on activated carbon;
In
methanol; dichloromethane; acetone;
