(2R,4S,5S,10S,11R,12S,15R)-2,12-Bis-benzyloxy-4,10-bis-(tert-butyl-dimethyl-silanyloxy)-15-(tert-butyl-diphenyl-silanyloxymethyl)-5,11-dimethyl-heptadecan-8-one

Base Information

Chemical Name:(2R,4S,5S,10S,11R,12S,15R)-2,12-Bis-benzyloxy-4,10-bis-(tert-butyl-dimethyl-silanyloxy)-15-(tert-butyl-diphenyl-silanyloxymethyl)-5,11-dimethyl-heptadecan-8-one
CAS No.:187862-89-1
Molecular Formula:C₆₂H₉₈O₆Si₃
Molecular Weight:1023.71
Hs Code.:

(2R,4S,5S,10S,11R,12S,15R)-2,12-Bis-benzyloxy-4,10-bis-(tert-butyl-dimethyl-silanyloxy)-15-(tert-butyl-diphenyl-silanyloxymethyl)-5,11-dimethyl-heptadecan-8-one

Synonyms:(2R,4S,5S,10S,11R,12S,15R)-2,12-Bis-benzyloxy-4,10-bis-(tert-butyl-dimethyl-silanyloxy)-15-(tert-butyl-diphenyl-silanyloxymethyl)-5,11-dimethyl-heptadecan-8-one

Suppliers and Price of (2R,4S,5S,10S,11R,12S,15R)-2,12-Bis-benzyloxy-4,10-bis-(tert-butyl-dimethyl-silanyloxy)-15-(tert-butyl-diphenyl-silanyloxymethyl)-5,11-dimethyl-heptadecan-8-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4S,5S,10S,11R,12S,15R)-2,12-Bis-benzyloxy-4,10-bis-(tert-butyl-dimethyl-silanyloxy)-15-(tert-butyl-diphenyl-silanyloxymethyl)-5,11-dimethyl-heptadecan-8-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4S,5S,10S,11R,12S,15R)-2,12-Bis-benzyloxy-4,10-bis-(tert-butyl-dimethyl-silanyloxy)-15-(tert-butyl-diphenyl-silanyloxymethyl)-5,11-dimethyl-heptadecan-8-one

There total 32 articles about (2R,4S,5S,10S,11R,12S,15R)-2,12-Bis-benzyloxy-4,10-bis-(tert-butyl-dimethyl-silanyloxy)-15-(tert-butyl-diphenyl-silanyloxymethyl)-5,11-dimethyl-heptadecan-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86040-07-5
(R)-3-benzyloxybutanal

: 187862-89-1
(2R,4S,5S,10S,11R,12S,15R)-2,12-Bis-benzyloxy-4,10-bis-(tert-butyl-dimethyl-silanyloxy)-15-(tert-butyl-diphenyl-silanyloxymethyl)-5,11-dimethyl-heptadecan-8-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 79 percent / TiCl₄ / CH₂Cl₂ / 12 h / -78 °C

2.1: 2,6-lutidine

3.1: O₃ / pyridine / methanol / -78 °C

3.2: Me₂S / methanol / -78 - 25 °C

4.1: 1.16 g / NaBH₄ / methanol / 0.5 h / 0 - 25 °C

5.1: 70 percent / (PhO)3PCH₃I / dimethylformamide / 1.5 h / 0 °C

6.1: LDA / tetrahydrofuran; various solvent(s) / 0.5 h / 0 °C

6.2: HMPA / tetrahydrofuran; various solvent(s) / 48 h / 0 °C

7.1: 950 mg / SiO₂ / ethyl acetate; various solvent(s) / 36 h

With 2,6-dimethylpyridine; sodium tetrahydroborate; methyltriphenoxyphosphonium iodide; silica gel; titanium tetrachloride; ozone; lithium diisopropyl amide; pyridine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo001767c

Reference yield:

: 187862-52-8
(E)-(5S,6S,9R)-6-Benzyloxy-9-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-undec-3-enoic acid methyl ester

: 187862-89-1
(2R,4S,5S,10S,11R,12S,15R)-2,12-Bis-benzyloxy-4,10-bis-(tert-butyl-dimethyl-silanyloxy)-15-(tert-butyl-diphenyl-silanyloxymethyl)-5,11-dimethyl-heptadecan-8-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: O₃ / pyridine / methanol / -78 °C

1.2: 89 percent / Me₂S / methanol / 12 h / -78 - 20 °C

2.1: 71 percent / TiCl₄ / CH₂Cl₂ / 1 h / -78 °C

3.1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 6 h / 0 °C

4.1: OsO₄; Me₃NO; water / 2-methyl-propan-2-ol; tetrahydrofuran; toluene

4.2: 75 percent / Pb(OAc)4 / diethyl ether / 0.25 h

5.1: 880 mg / TMSCl / 15 h / 0 - 25 °C

6.1: LDA / tetrahydrofuran; various solvent(s) / 0.5 h / 0 °C

6.2: HMPA / tetrahydrofuran; various solvent(s) / 48 h / 0 °C

7.1: 950 mg / SiO₂ / ethyl acetate; various solvent(s) / 36 h

With 2,6-dimethylpyridine; osmium(VIII) oxide; chloro-trimethyl-silane; trimethylamine-N-oxide; water; silica gel; titanium tetrachloride; ozone; lithium diisopropyl amide; pyridine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene; tert-butyl alcohol;
DOI:10.1021/jo001767c

Reference yield:

: 187862-43-7
(R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-hexanal

: 187862-89-1
(2R,4S,5S,10S,11R,12S,15R)-2,12-Bis-benzyloxy-4,10-bis-(tert-butyl-dimethyl-silanyloxy)-15-(tert-butyl-diphenyl-silanyloxymethyl)-5,11-dimethyl-heptadecan-8-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: 89 percent / TMSOTf / CH₂Cl₂ / 37 h / -78 - -55 °C

2.1: O₃ / pyridine / methanol / -78 °C

2.2: 89 percent / Me₂S / methanol / 12 h / -78 - 20 °C

3.1: 71 percent / TiCl₄ / CH₂Cl₂ / 1 h / -78 °C

4.1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 6 h / 0 °C

5.1: OsO₄; Me₃NO; water / 2-methyl-propan-2-ol; tetrahydrofuran; toluene

5.2: 75 percent / Pb(OAc)4 / diethyl ether / 0.25 h

6.1: 880 mg / TMSCl / 15 h / 0 - 25 °C

7.1: LDA / tetrahydrofuran; various solvent(s) / 0.5 h / 0 °C

7.2: HMPA / tetrahydrofuran; various solvent(s) / 48 h / 0 °C

8.1: 950 mg / SiO₂ / ethyl acetate; various solvent(s) / 36 h

With 2,6-dimethylpyridine; osmium(VIII) oxide; chloro-trimethyl-silane; trimethylamine-N-oxide; trimethylsilyl trifluoromethanesulfonate; water; silica gel; titanium tetrachloride; ozone; lithium diisopropyl amide; pyridine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene; tert-butyl alcohol;
DOI:10.1021/jo001767c