methyl 4-(hydroxy(4-methoxyphenyl)methyl)-2-phenyl-3-furoate

Base Information

• Chemical Name: methyl 4-(hydroxy(4-methoxyphenyl)methyl)-2-phenyl-3-furoate
• CAS No.: 1357154-68-7
• Molecular Formula: C₂₀H₁₈O₅
• Molecular Weight: 338.36
• Mol file: 1357154-68-7.mol

Synonyms:methyl 4-(hydroxy(4-methoxyphenyl)methyl)-2-phenyl-3-furoate

Chemical Property of methyl 4-(hydroxy(4-methoxyphenyl)methyl)-2-phenyl-3-furoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl 4-(hydroxy(4-methoxyphenyl)methyl)-2-phenyl-3-furoate

There total 5 articles about methyl 4-(hydroxy(4-methoxyphenyl)methyl)-2-phenyl-3-furoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 4-(4-methoxybenzoyl)-2-phenyl-3-furoate (264121-01-9) → methyl 4-(hydroxy(4-methoxyphenyl)methyl)-2-phenyl-3-furoate (1357154-68-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h; under 76005.1 Torr; Inert atmosphere;

DOI:10.1039/c1ob06560b

Reference yield: 35.0%

methyl 4-(4-methoxybenzoyl)-2-phenyl-3-furoate (264121-01-9) → methyl 4-(4-m ethoxybenzyl)-2-phenylfuran-3-carboxylate (1357154-69-8) + methyl 4-(hydroxy(4-methoxyphenyl)methyl)-2-phenyl-3-furoate (1357154-68-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 50 ℃; for 12h; under 76005.1 Torr; Inert atmosphere;

DOI:10.1039/c1ob06560b

Reference yield:

methoxybenzene (100-66-3) → methyl 4-(hydroxy(4-methoxyphenyl)methyl)-2-phenyl-3-furoate (1357154-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoromethylsulfonic anhydride / 12 h / -30 °C / Inert atmosphere; neat (no solvent)

2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C / 76005.1 Torr / Inert atmosphere

With trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; hydrogen; In methanol; 1: Friedel Crafts acylation;

DOI:10.1039/c1ob06560b

upstream raw materials:

methyl 4-(4-methoxybenzoyl)-2-phenyl-3-furoate

methoxybenzene

3-methoxycarbonyl-2-phenylfuran-4-carboxylic acid