N-[4-chloro-6-(4-trifluoromethyl-phenylamino)-pyrimidin-5-yl]-2-(2,6-dichloro-phenyl)-acetamide

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Chemical Name:N-[4-chloro-6-(4-trifluoromethyl-phenylamino)-pyrimidin-5-yl]-2-(2,6-dichloro-phenyl)-acetamide
CAS No.:1160608-92-3
Molecular Formula:C₁₉H₁₂Cl₃F₃N₄O
Molecular Weight:475.685
Hs Code.:

Synonyms:N-[4-chloro-6-(4-trifluoromethyl-phenylamino)-pyrimidin-5-yl]-2-(2,6-dichloro-phenyl)-acetamide

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Chemical Property of N-[4-chloro-6-(4-trifluoromethyl-phenylamino)-pyrimidin-5-yl]-2-(2,6-dichloro-phenyl)-acetamide

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Technology Process of N-[4-chloro-6-(4-trifluoromethyl-phenylamino)-pyrimidin-5-yl]-2-(2,6-dichloro-phenyl)-acetamide

There total 4 articles about N-[4-chloro-6-(4-trifluoromethyl-phenylamino)-pyrimidin-5-yl]-2-(2,6-dichloro-phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 882769-94-0
6-chloro-N⁽⁴⁾-(4-trifluoromethylphenyl)pyrimidine-4,5-diamine

: 61875-53-4
2,6-dichlorophenylacetylchloride

: 1160608-92-3
N-[4-chloro-6-(4-trifluoromethyl-phenylamino)-pyrimidin-5-yl]-2-(2,6-dichloro-phenyl)-acetamide

Guidance literature:: In N,N-dimethyl acetamide; at 20 ℃; for 1h;
DOI:10.1021/op1002984

Reference yield: 64.0%

: 1160608-91-2
6-chloro-N₄-(4-trifluoromethyl-phenyl)-pyrimidine-4,5-diamine hydrochloride

: 61875-53-4
2,6-dichlorophenylacetylchloride

: 1160608-92-3
N-[4-chloro-6-(4-trifluoromethyl-phenylamino)-pyrimidin-5-yl]-2-(2,6-dichloro-phenyl)-acetamide

Guidance literature:: In N,N-dimethyl acetamide; for 2h;

Reference yield:

: 6575-24-2
2-(2,6-dichlorophenyl)acetic acid

: 1160608-92-3
N-[4-chloro-6-(4-trifluoromethyl-phenylamino)-pyrimidin-5-yl]-2-(2,6-dichloro-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / toluene / 12 h / 20 °C

2: N,N-dimethyl acetamide / 1 h / 20 °C

With thionyl chloride; In N,N-dimethyl acetamide; toluene;
DOI:10.1021/op1002984