61875-53-4

Basic information

• Product Name: 2,6-Dichlorophenylacetic acid chloride
• Synonyms: 2,6-Dichlorophenylacetic acid chloride;2-(2,6-Dichlorophenyl)acetyl chloride;2-(2,6-Dichorophenyl)acetyl chloride
• CAS NO: 61875-53-4
• Molecular Formula: C₈H₅Cl₃O
• Molecular Weight: 223.49
• Mol File: 61875-53-4.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,6-Dichlorophenylacetic acid chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichlorophenylacetic acid chloride(61875-53-4)
• EPA Substance Registry System: 2,6-Dichlorophenylacetic acid chloride(61875-53-4)

Safety Data

• Hazardous Substances Data: 61875-53-4(Hazardous Substances Data)

Usage

Molecular weight

191.03 g/mol

Chemical structure

A phenyl ring with two chlorine atoms attached to the 2 and 6 positions, and an acetyl chloride group attached to the phenyl ring.

Appearance

White to off-white crystalline solid.

Melting point

70-73°C

Boiling point

140-145°C (decomposes)

Solubility

Slightly soluble in water, soluble in organic solvents such as ethanol, ether, and chloroform.

Reactivity

Reacts with nucleophiles and bases, can undergo substitution reactions.

Uses

Building block in organic synthesis, used to create various compounds including pharmaceuticals and agrochemicals.

Handling precautions

Corrosive and harmful if it comes into contact with skin or eyes, should be handled in a controlled laboratory setting by trained professionals.

Upstream product

• 2014-83-7 1,3-Dichloro-2-chloromethyl-benzene 
• 3215-64-3 2,6-dichlorophenylacetonitrile 
• 6575-24-2 2-(2,6-dichlorophenyl)acetic acid 

Downstream Products

• 56636-71-6 (2,6-Dichloro-phenyl)-ethaneperoxoic acid tert-butyl ester 
• 153529-20-5 2-(2,6-Dichloro-phenyl)-1-(4-methoxy-phenyl)-ethanone 
• 78622-22-7 2-(2,6-dichlorophenyl)acetylurea 
• 74689-60-4 C₉H₆Cl₂N₂O 
• 119930-39-1 1,3-Dichloro-2-phenylselanylmethyl-benzene 
• 15258-73-8 2,6-dichlorobenzyl alcohol 
• 62120-70-1 1,2-bis-(2,6-dichlorophenyl)ethane 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 20443-98-5 2,6-Dichlorobenzyl bromide 
• 70925-85-8 2-(2,6-dichlorophenyl)acetyl isothiocyanate 
• 77583-72-3 2-chloro-2-(2,6-dichlorophenyl) acetylchloride 
• 119423-07-3 5-(2-chloroethyl)-5'-[2-(2,6-dichlorophenyl)acetamido]-2',5'-dideoxyuridine 
• 1186621-86-2 5-[(2,6-dichlorobenzyl)carbonyl]amino-8-isopentyl-2-(2-furyl)-pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine 
• 46999-59-1 N''-[2-(2,6-Dichloro-phenyl)-acetyl]-N,N,N',N'-tetramethyl-guanidine 

Relevant articles and documents

N-arylacetyl thiosemicarbazide urease inhibitor and preparation method and application thereof

N-arylacetyl thiosemicarbazide compounds have a structural formula as shown in the specification, have great inhibiting effects on urease and can be used for preparation of medicines for treating gastritis, gastric ulcer, lithangiuria and the like. The in

Synthesis of Unsymmetrical Diaryl Acetamides, Benzofurans, Benzophenones, and Xanthenes by Transition-Metal-Free Oxidative Cross-Coupling of sp3 and sp2 C-H Bonds

A chemo- and regioselective intermolecular sp3 C-H and sp2 C-H coupling reaction for C-C bond formation is described to access unsymmetrical diaryl acetamides under TM-free conditions from sec- and tert-arylacetamides and nitroarenes using tert-butoxide base in DMSO at room temperature. The coupling partners with sensitive functionalities such as chloro, bromo, hydroxy, and cyano were also amenable to the developed reaction. Synthesized α-(2/4-nitroaryl) phenylacetamides have been transformed into biologically important benzofurans, xanthenes, diaryl indoles, and unsymmetrical benzophenones by novel routes without applying a transition metal. Overall, an economical, yet efficient, strategy has been devised to access unsymmetrical diarylacetamides with the possibility of their further elaboration into a variety of biologically important heterocycles. Mechanistic understanding suggests that the reaction proceeds by a nucleophilic addition of a phenylacetamide carbanion, which is generated in the presence of tert-butoxide base, to the para or ortho (if para is substituted) position of nitrobenzene. The formed α-(4-nitrocyclohexa-2,4-dien-1-yl) phenylacetamide anion intermediate oxidized by a basic solution of DMSO or atmospheric oxygen led to the desired sp3 C-H and sp2 C-H coupled α-(2/4-nitroaryl) phenylacetamides.

AMINOPYRIDINE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS

The invention relates to compound of the formula (I) in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.