5-butyl-1-[[2'-(tert-butoxycarbonyl)biphenyl-4-yl]methyl]-2-hydroxymethyl-3-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazolium bromide

Base Information

Chemical Name:5-butyl-1-[[2'-(tert-butoxycarbonyl)biphenyl-4-yl]methyl]-2-hydroxymethyl-3-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazolium bromide
CAS No.:1400934-18-0
Molecular Formula:Br*C₃₂H₄₇N₂O₄Si
Molecular Weight:631.726
Hs Code.:

Synonyms:5-butyl-1-[[2'-(tert-butoxycarbonyl)biphenyl-4-yl]methyl]-2-hydroxymethyl-3-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazolium bromide

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Chemical Property of 5-butyl-1-[[2'-(tert-butoxycarbonyl)biphenyl-4-yl]methyl]-2-hydroxymethyl-3-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazolium bromide

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Technology Process of 5-butyl-1-[[2'-(tert-butoxycarbonyl)biphenyl-4-yl]methyl]-2-hydroxymethyl-3-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazolium bromide

There total 11 articles about 5-butyl-1-[[2'-(tert-butoxycarbonyl)biphenyl-4-yl]methyl]-2-hydroxymethyl-3-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazolium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1400934-15-7
5-butyl-1-[[2'-(tert-butoxycarbonyl)biphenyl-4-yl]methyl]-3-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazolium bromide

: 1400934-18-0
5-butyl-1-[[2'-(tert-butoxycarbonyl)biphenyl-4-yl]methyl]-2-hydroxymethyl-3-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazolium bromide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 85 ℃; for 1h; Sealed tube;
DOI:10.1016/j.ejmech.2012.07.040

Reference yield:

: 100-47-0
benzonitrile

: 1400934-18-0
5-butyl-1-[[2'-(tert-butoxycarbonyl)biphenyl-4-yl]methyl]-2-hydroxymethyl-3-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazolium bromide

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium; 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran; hexane / 0.08 h / -78 - -10 °C / Inert atmosphere

1.2: 5 h / -78 - 20 °C / Inert atmosphere

2.1: toluene / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene / 4 h / 100 °C / Inert atmosphere

4.1: hydrogenchloride; water / 12 h / Reflux

5.1: oxalyl dichloride / dichloromethane / 3 h / 0 - 20 °C

5.2: 1 h / 10 - 20 °C

6.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 8 h / Reflux

7.1: acetonitrile / 3 h / Reflux; Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 85 °C / Sealed tube

With hydrogenchloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; oxalyl dichloride; 2,2,6,6-tetramethylpiperidinyl-lithium; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 3.1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2012.07.040

Reference yield:

: C₁₃H₁₈BNO₂

: 1400934-18-0
5-butyl-1-[[2'-(tert-butoxycarbonyl)biphenyl-4-yl]methyl]-2-hydroxymethyl-3-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazolium bromide

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene / 4 h / 100 °C / Inert atmosphere

3.1: hydrogenchloride; water / 12 h / Reflux

4.1: oxalyl dichloride / dichloromethane / 3 h / 0 - 20 °C

4.2: 1 h / 10 - 20 °C

5.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 8 h / Reflux

6.1: acetonitrile / 3 h / Reflux; Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 85 °C / Sealed tube

With hydrogenchloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 2.1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2012.07.040