tert-butyl trans-[4-(triphenylmethylamino)cyclohexylamino]acetate

Base Information

• Chemical Name: tert-butyl trans-[4-(triphenylmethylamino)cyclohexylamino]acetate
• CAS No.: 174775-06-5
• Molecular Formula: C₃₁H₃₈N₂O₂
• Molecular Weight: 470.655
• Mol file: 174775-06-5.mol

Synonyms:tert-butyl trans-[4-(triphenylmethylamino)cyclohexylamino]acetate

Chemical Property of tert-butyl trans-[4-(triphenylmethylamino)cyclohexylamino]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl trans-[4-(triphenylmethylamino)cyclohexylamino]acetate

There total 3 articles about tert-butyl trans-[4-(triphenylmethylamino)cyclohexylamino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

bromoacetic acid tert-butyl ester (5292-43-3) + trans-1-amino-4-(triphenylmethylamino)cyclohexane (174774-98-2) → tert-butyl trans-[4-(triphenylmethylamino)cyclohexylamino]acetate (174775-06-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

DOI:10.1248/cpb.47.1694

Reference yield:

trans-1,4-cyclohexyldiamine (2615-25-0) → tert-butyl trans-[4-(triphenylmethylamino)cyclohexylamino]acetate (174775-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent / TEA / CH₂Cl₂

2: 83 percent / K₂CO₃ / dimethylformamide / 0.5 h / 20 °C

With TEA; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Alkylation;

DOI:10.1248/cpb.47.1694

Reference yield:

trityl chloride (76-83-5) → tert-butyl trans-[4-(triphenylmethylamino)cyclohexylamino]acetate (174775-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent / TEA / CH₂Cl₂

2: 83 percent / K₂CO₃ / dimethylformamide / 0.5 h / 20 °C

With TEA; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Alkylation;

DOI:10.1248/cpb.47.1694

upstream raw materials:

bromoacetic acid tert-butyl ester

trans-1-amino-4-(triphenylmethylamino)cyclohexane

trans-1,4-cyclohexyldiamine

trityl chloride

Downstream raw materials:

tert-butyl trans-[4-(triphenylmethylamino)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate