tert-butyl trans-[4-(triphenylmethylamino)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate

Base Information

• Chemical Name: tert-butyl trans-[4-(triphenylmethylamino)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate
• CAS No.: 174775-07-6
• Molecular Formula: C₃₆H₄₆N₂O₄
• Molecular Weight: 570.772
• Mol file: 174775-07-6.mol

Synonyms:tert-butyl trans-[4-(triphenylmethylamino)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate

Chemical Property of tert-butyl trans-[4-(triphenylmethylamino)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl trans-[4-(triphenylmethylamino)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate

There total 5 articles about tert-butyl trans-[4-(triphenylmethylamino)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

di-tert-butyl dicarbonate (24424-99-5) + tert-butyl trans-[4-(triphenylmethylamino)cyclohexylamino]acetate (174775-06-5) → tert-butyl trans-[4-(triphenylmethylamino)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate (174775-07-6)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1248/cpb.47.1694

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → tert-butyl trans-[4-(triphenylmethylamino)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate (174775-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / K₂CO₃ / dimethylformamide / 0.5 h / 20 °C

2: 63 percent / 4-dimethylaminopyridine; pyridine / CH₂Cl₂ / 2 h / 0 °C

With pyridine; dmap; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Acylation;

DOI:10.1248/cpb.47.1694

Reference yield:

trans-1,4-cyclohexyldiamine (2615-25-0) → tert-butyl trans-[4-(triphenylmethylamino)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate (174775-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 30 percent / TEA / CH₂Cl₂

2: 83 percent / K₂CO₃ / dimethylformamide / 0.5 h / 20 °C

3: 63 percent / 4-dimethylaminopyridine; pyridine / CH₂Cl₂ / 2 h / 0 °C

With pyridine; dmap; TEA; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Alkylation / 3: Acylation;

DOI:10.1248/cpb.47.1694

upstream raw materials:

di-tert-butyl dicarbonate

tert-butyl trans-[4-(triphenylmethylamino)cyclohexylamino]acetate

bromoacetic acid tert-butyl ester

trans-1,4-cyclohexyldiamine

Downstream raw materials:

tert-butyl trans-[4-aminocyclohexyl-N-(tert-butoxycarbonyl)amino]acetate